Ticking time bombs: connections between circadian clocks and cancer.
Ticking time bombs: connections between circadian clocks and cancer.
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DOI：
10.12688/f1000research.11770.1
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发表时间：
2017
期刊：
影响因子：
--
通讯作者：
Lamia KA
中科院分区：
文献类型：
--
作者：
Lamia KA
自世纪初以来，哺乳动物昼夜节律和细胞分裂周期之间的联系就已被假定，流行病学和遗传学研究将昼夜节律钟功能的破坏与几种癌症的风险增加联系起来。在过去的十年中，人们已经清楚，生物钟组件影响细胞的生长和转化，在细胞自主的方式。此外，已经描述了几种分子机制连接，其中时钟蛋白参与感知DNA损伤，调节DNA修复，并影响肿瘤发生（c-MYC）和肿瘤抑制（p53）中关键参与者的泛素化和降解。
Connections between mammalian circadian and cell division cycles have been postulated since the early 20th century, and epidemiological and genetic studies have linked disruption of circadian clock function to increased risk of several types of cancer. In the past decade, it has become clear that circadian clock components influence cell growth and transformation in a cell-autonomous manner. Furthermore, several molecular mechanistic connections have been described in which clock proteins participate in sensing DNA damage, modulating DNA repair, and influencing the ubiquitination and degradation of key players in oncogenesis (c-MYC) and tumor suppression (p53).