Image quality evaluation of projection- and depth dose-based approaches to integrating proton radiography using a monolithic scintillator detector.
Image quality evaluation of projection- and depth dose-based approaches to integrating proton radiography using a monolithic scintillator detector.
复制标题
使用单片闪烁体探测器集成质子射线照相的基于投影和深度剂量的方法的图像质量评估。
DOI：
10.1088/1361-6560/ac0cc3
复制
发表时间：
2021
影响因子：
3.5
通讯作者：
Beddar,Sam
中科院分区：
文献类型：
--
作者：
Tendler,Irwin;Robertson,Daniel;Darne,Chinmay;Panthi,Rajesh;Alsanea,Fahed;Collins-Fekete,Charles-Antoine;Beddar,Sam
本研究的目的是比较集成质子放射成像（PR）系统的图像质量，该系统由一个单片闪烁体和两台数码相机组成，使用积分横向剂量和积分深度剂量图像重建技术。利用蒙特卡罗模拟获得了三维单片闪烁体探测器（30× 30× 30 cm 3聚乙烯基甲苯有机闪烁体）中的能量沉积，从而产生了各种幻像的射线照片——用于空间分辨率分析的斜铝立方体和用于对比度分析的拉斯维加斯幻像。利用Birks闪烁模型对闪烁体的光发射进行了校正。我们比较了两种整合PR方法和理想的质子跟踪射线照相系统的预期结果。本研究使用了四种不同的图像重建方法：光束眼视图投影的积分闪烁光、经过优化和未经过优化的基于深度剂量的重建方法，以及参考数据采用单粒子跟踪PR。结果表明，在空中模拟的拉斯维加斯幻影中发现了介质界面失配引起的非均质伪影。发现单事件重建的空间分辨率最高。对比水平，从最好到最差，被发现对应于粒子跟踪、优化深度剂量、深度剂量和基于投影的图像重建。集成PR系统的单片闪烁体的图像质量足以保证进一步的探索。这些结果显示了潜在的临床应用前景，作为质子放疗期间可视化患者内部解剖的放射技术。
The purpose of this study is to compare the image quality of an integrating proton radiography (PR) system, composed of a monolithic scintillator and two digital cameras, using integral lateral-dose and integral depth-dose image reconstruction techniques. Monte Carlo simulations were used to obtain the energy deposition in a 3D monolithic scintillator detector (30× 30× 30 cm 3 poly vinyl toluene organic scintillator) to create radiographs of various phantoms—a slanted aluminum cube for spatial resolution analysis and a Las Vegas phantom for contrast analysis. The light emission of the scintillator was corrected using Birks scintillation model. We compared two integrating PR methods and the expected results from an idealized proton tracking radiography system. Four different image reconstruction methods were utilized in this study: integral scintillation light projected from the beams-eye view, depth-dose based reconstruction methods both with and without optimization, and single particle tracking PR was used for reference data. Results showed that heterogeneity artifact due to medium-interface mismatch was identified from the Las Vegas phantom simulated in air. Spatial resolution was found to be highest for single-event reconstruction. Contrast levels, ranked from best to worst, were found to correspond to particle tracking, optimized depth-dose, depth-dose, and projection-based image reconstructions. The image quality of a monolithic scintillator integrating PR system was sufficient to warrant further exploration. These results show promise for potential clinical use as radiographic techniques for visualizing internal patient anatomy during proton radiotherapy.