Prevalence of Autism Spectrum Disorders in Siblings of Indian Children With Autism Spectrum Disorders
Prevalence of Autism Spectrum Disorders in Siblings of Indian Children With Autism Spectrum Disorders
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DOI：
10.1177/0883073815624764
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发表时间：
2016-06-01
影响因子：
1.9
通讯作者：
Mishra, Devendra
中科院分区：
文献类型：
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作者：
Kumar, Ankur;Juneja, Monica;Mishra, Devendra
这项研究确定了201名自闭症谱系障碍儿童的兄弟姐妹中自闭症谱系障碍的患病率。采用儿童孤独症量表和父母版社会反应量表进行筛查。筛查阳性的兄弟姐妹使用精神障碍诊断和统计手册（第四版）标准进行评估。兄弟姐妹中自闭症谱系障碍的风险与索引病例的各种家族和疾病特征相关。孤独症谱系障碍患病率为4.97%。有一个显着的影响存在的攻击性行为，外化问题和总的问题，先证者，评估使用儿童行为检查表，和年轻的父亲在怀孕的兄弟姐妹自闭症谱系障碍的风险。我们的研究结果与之前报道的类似患病率的研究结果一致，但也提出了与行为问题的关联作为一个可能的风险因素。患有自闭症谱系障碍的儿童应进行常规筛查，并应向家庭解释这种风险增加的遗传咨询。
This study determined the prevalence of autism spectrum disorders in 201 siblings of children with autism spectrum disorders. Siblings were screened using Modified Checklist for Autism in Toddlers and Social Responsiveness Scale, parent version. Screen-positive siblings were assessed using Diagnostic and Statistical Manual of Mental Disorders (Fourth Edition) criteria. The risk of autism spectrum disorder in siblings was correlated with various familial and disease characteristics of the index case. Prevalence of autism spectrum disorder in siblings was 4.97%. There was a significant effect of the presence of aggressive behavior, externalizing problems and total problems in the proband, assessed using Childhood Behavior Checklist, and the young age of the father at conception on sibling risk of autism spectrum disorder. Results of our study are in line with previous studies reporting similar prevalence but have also brought up the association with behavioral problems as a possible risk factor. Siblings of children with autism spectrum disorder should be routinely screened, and genetic counseling for this increased risk should be explained to the family.