Association of body mass index and weight change with all-cause mortality in the elderly
Association of body mass index and weight change with all-cause mortality in the elderly
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DOI：
10.1093/aje/kwj114
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发表时间：
2006-05-15
影响因子：
5
通讯作者：
Paganini-Hill, A
中科院分区：
文献类型：
--
作者：
Corrada, MM;Kawas, CH;Paganini-Hill, A
作者利用加州一项基于人群的大型队列研究--休闲世界队列研究的数据，探索了体重指数(BMI；体重(公斤)/身高(M)(2))和体重变化与老年人全因死亡率的关系。他们估计了与研究开始时自我报告的BMI、21岁的BMI以及21岁到研究开始之间的体重变化相关的死亡相对风险。参与者被归类为体重不足(BMI<；18.5)、正常体重(BMI 18.5-24.9)、超重(BMI 25-29.9)或肥胖(BMI<；=30)。在研究开始时(1981-1985年)的13,451名参与者中，平均年龄为73岁，其中11,203人在23年的随访(1981-2004年)中死亡。相对于正常体重，研究开始时体重不足(相对危险度(RR)=1.51，95%可信区间(CI)：1.38，1.65)或肥胖(RR=1.25，95%CI：1.13，1.38)与死亡率增加相关。在21岁时超重或肥胖的人死亡率也增加(RR=1.17，95%CI：1.09，1.25)。在21岁到研究开始之间体重减轻的参与者在21岁时无论他们的BMI类别如何，死亡率都会增加。只有在75岁以下的人和从不吸烟者或过去吸烟者中，肥胖与死亡率的增加显著相关。这项研究强调了年轻时超重或肥胖以及晚年体重不足或肥胖对老年死亡率的影响。
The authors explored the relation of body mass index (BMI; weight (kg)/height (m)(2)) and weight change to all-cause mortality in the elderly, using data from a large, population-based California cohort study, the Leisure World Cohort Study. They estimated relative risks of mortality associated with self-reported BMI at study entry, BMI at age 21 years, and weight change between age 21 and study entry. Participants were categorized as underweight (BMI < 18.5), normal weight (BMI 18.5-24.9), overweight (BMI 25-29.9), or obese (BMI >= 30). Of 13,451 participants aged 73 years (on average) at study entry (1981-1985), 11,203 died during 23 years of follow-up (1981-2004). Relative to normal weight, being underweight (relative risk (RR) = 1.51, 95% confidence interval (CI): 1.38, 1.65) or obese (RR = 1.25, 95% CI: 1.13, 1.38) at study entry was associated with increased mortality. People who were either overweight or obese at age 21 also had increased mortality (RR = 1.17, 95% CI: 1.09, 1.25). Participants who lost weight between age 21 and study entry had increased mortality regardless of their BMI category at age 21. Obesity was significantly associated with increased mortality only among persons under age 75 years and among never or past smokers. This study highlights the influence on older-age mortality risk of being overweight or obese in young adulthood and underweight or obese in later life.