Moonlighting proteins in cancer.
Moonlighting proteins in cancer.
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DOI：
10.1016/j.canlet.2015.09.022
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发表时间：
2016-01-01
期刊：
影响因子：
9.7
通讯作者：
Baek SJ
中科院分区：
文献类型：
--
作者：
Min KW;Lee SH;Baek SJ
自20世纪80年代以来，越来越多的证据表明，蛋白质的细胞定位决定了它们的活性和生物学功能。在经典观点中，蛋白质的特征在于其主要驻留和发挥功能的单个细胞区室。现在人们认为，当蛋白质出现在不同的亚细胞位置时，细胞超过了给定相同基因组信息的蛋白质的预期活性，以实现复杂的生物学行为。许多蛋白质被认为具有存在于细胞中多个位置的潜力。易位失调可能导致癌症或导致癌症预后不良。因此，动态蛋白质和相关蛋白质运动的定量和综合评估可能是确定癌症预后和癌症治疗和治疗效率的有希望的指标。本文将总结这些所谓的兼职蛋白，在耦合的细胞内癌症信号通路。测定兼职蛋白的详细生物细胞内和细胞外转运和调节活性，可以更好地了解癌症和鉴定分子干预的潜在手段。
Since the 1980s, growing evidence suggested that the cellular localization of proteins determined their activity and biological functions. In a classical view, a protein is characterized by the single cellular compartment where it primarily resides and functions. It is now believed that when proteins appear in different subcellular locations, the cells surpass the expected activity of proteins given the same genomic information to fulfill complex biological behavior. Many proteins are recognized for having the potential to exist in multiple locations in cells. Dysregulation of translocation may cause cancer or contribute to poorer cancer prognosis. Thus, quantitative and comprehensive assessment of dynamic proteins and associated protein movements could be a promising indicator in determining cancer prognosis and efficiency of cancer treatment and therapy. This review will summarize these so-called moonlighting proteins, in terms of a coupled intracellular cancer signaling pathway. Determination of the detailed biological intracellular and extracellular transit and regulatory activity of moonlighting proteins permits a better understanding of cancer and identification of potential means of molecular intervention.