Interaction of kanamycin and ethacrynic acid. Severe cochlear damage in guinea pigs.
Interaction of kanamycin and ethacrynic acid. Severe cochlear damage in guinea pigs.
复制标题
卡那霉素和依他尼酸的相互作用。
DOI：
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发表时间：
1973
期刊：
影响因子：
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通讯作者：
D. Himes
中科院分区：
文献类型：
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作者：
B. West;R. Brummett;D. Himes
在实验动物中证实了对接受卡那霉素治疗的患者给予依他尼酸可导致永久性听力损失的临床观察结果。我们已经证明，豚鼠皮下接受400 mg/kg卡那霉素的负荷剂量，然后在两小时内静脉注射40 mg/kg依他尼酸，永久丧失其耳蜗功能。该效应在依他尼酸注射后约两小时发生，似乎是通过与先前报道的产生初始暂时效应的机制不同的机制发生的。由于这种可能的相互作用，在肾衰竭患者中同时使用氨基糖苷类抗生素和依他尼酸时必须谨慎。
The clinical observation that ethacrynic acid administration to patients receiving kanamycin therapy can result in a permanent hearing loss has been verified in experimental animals. We have demonstrated that guinea pigs receiving a loading dose of 400 mg/kg of kanamycin subcutaneously, followed in two hours by an intravenous injection of 40 mg/kg of ethacrynic acid, lose their cochlear function permanently. The effect occurs approximately two hours after the injection of ethacrynic acid and seems to occur by a different mechanism than that which produces the initial temporary effect previously reported. Because of this possible interaction, caution must be exercised when employing an aminoglycoside antibiotic and ethacrynic acid together in patients with renal failure.