Latent gene sequencing reveals familial relationships among chinese Epstein-Barr virus strains and evidence for positive selection of all epitope changes
Latent gene sequencing reveals familial relationships among chinese Epstein-Barr virus strains and evidence for positive selection of all epitope changes
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DOI：
10.1128/jvi.77.21.11517-11530.2003
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发表时间：
2003-11-01
影响因子：
5.4
通讯作者：
Rickinson, AB
中科院分区：
文献类型：
--
作者：
Midgley, RS;Bell, AI;Rickinson, AB
EB病毒(Epstein-Barr Virus，EBV)分离株主要为1型，其核抗原EBNA3B序列(相对于当代高加索原型株B95.8)有多种序列变化(相对于当代高加索原型株B95.8)，编码两个主要的免疫表位，这里称为IVT和AVF。这被一些人解释为免疫选择的证据，另一些人则被解释为随机遗传漂移。为了在更广泛的基因组背景下研究表位变异，我们对31株中国EBV分离株的EBNA3B全序列和EBNA2、3A和3C基因的部分序列进行了测序。在每个基因座上，1型病毒都显示出
Epstein-Barr virus (EBV) strains from the highly HLA-A11-positive Chinese population are predominantly type 1 and show a variety of sequence changes (relative to the contemporary Caucasian prototype strain B95.8) in the nuclear antigen EBNA3B sequences encoding two immunodominant HLA-A11 epitopes, here called IVT and AVF. This has been interpreted by some as evidence of immune selection and by others as random genetic drift. To study epitope variation in a broader genomic context, we sequenced the whole of EBNA3B and parts of the EBNA2, 3A, and 3C genes from each of 31 Chinese EBV isolates. At each locus, type 1 viruses showed