High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction
High serum antibody levels to Porphyromonas gingivalis predict myocardial infarction
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DOI：
10.1097/00149831-200410000-00008
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发表时间：
2004-10-01
影响因子：
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通讯作者：
Jousilahti, P
中科院分区：
文献类型：
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作者：
Pussinen, PJ;Alfthan, G;Jousilahti, P
背景在一些流行病学研究中已经发现冠心病（CHID）和临床诊断的牙周炎之间存在关联。然而，血清流行病学证据的前瞻性数据的基础上，这种协会是完全lack.Design-研究的目的是调查血清抗体的主要牙周病原体的预测心肌梗死（MI）的男性无CHD在baseline.Methods病例和对照组确定从一个随机的人口样本4255名男性年龄在30至59岁的基线。研究病例包括63名在10年随访时间内患有非致命性MI或冠状动脉死亡的男性。年龄匹配的对照受试者（n=63）从同一队列中随机选择。结果MI的危险性与抗放线菌伴放线杆菌（Actinobacillusactinomycetemcomitans）和牙龈卟啉单胞菌（Porphyromonasgingivalis.Results）IgG或IgA类抗体水平无显著相关性。伴随放线菌或牙龈卟啉单胞菌的IgG类抗体水平。然而，高牙龈卟啉单胞菌IgA类抗体水平预测MI独立的经典心血管危险因素。随着抗体水平四分位数的增加，MI的风险增加（趋势P <0.021）。与第一四分位数相比，第二、三、四四分位数MI的多变量优势比为2.47（95% CI 0.75-8.11），3.30（1.03-10.58）和3.99结论本研究为牙周致病菌P，gingivalis，会增加心肌梗死的风险。(C)2004年欧洲心脏病学会。
Background An association between coronary heart disease (CHID) and clinically diagnosed periodontitis has been found in several epidemiological studies. However, seroepidemiologic evidence based on prospective data on this association is totally lacking.Design The aim of the study was to investigate serum antibodies to major periodontal pathogens for their prediction of myocardial infarction (MI) in men free of CHD at baseline.Methods Cases and controls were ascertained from a random population sample of 4255 men aged 30 to 59 years at baseline. The study cases included 63 men with nonfatal MI or coronary death within the follow-up time of 10 years. Agematched control subjects (n=63) were randomly chosen from the same cohort. Serum antibody levels to two major periodontopathogenic bacteria, Actinobacillus actinomycetemcomitans and Porphyromonas gingivalis, were determined.Results There was no significant association between the risk for MI and IgG- or IgA-class antibody levels to A. actinomycetemcomitans or IgG-class antibody levels to P. gingivalis. However, a high P gingivalis IgA-class antibody level predicted MI independently of classical cardiovascular risk factors. The risk for MI increased by increasing quartiles of antibody levels (P for the trend 0.021). Compared with the first quartile, the multivariate odds ratios of MI in the second, third and fourth quartiles were 2.47 (95% CI 0.75-8.11), 3.30 (1.03-10.58) and 3.99 (1.22-13.10), respectively.Conclusion The study provides serological evidence that an infection caused by the periodontal pathogen, P, gingivalis, increases the risk for MI. (C) 2004 The European Society of Cardiology.