Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast.
Identification of negative regulatory genes that govern the expression of early meiotic genes in yeast.
复制标题
鉴定控制酵母中早期减数分裂基因表达的负调控基因。
DOI：
10.1073/pnas.86.24.10018
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发表时间：
1989
影响因子：
11.1
通讯作者：
Esposito,RE
中科院分区：
文献类型：
--
作者：
Strich,R;Slater,MR;Esposito,RE
酿酒酵母中的突变已经被鉴定为去抑制在正常减数分裂发育所需的可分离途径中起作用的早期减数分裂基因。这些非程序性减数分裂基因表达突变的表型表明，它们的野生型等位基因编码负调控因子，作用于减数分裂的细胞类型和营养控制的下游。这些新定义的基因座不影响一般的转录或减数分裂基因的转录后，在减数分裂和孢子形成。
Mutations in Saccharomyces cerevisiae have been identified that derepress early meiotic genes functioning in separable pathways required for normal meiotic development. The phenotypes of these ume (unscheduled meiotic gene expression) mutations suggest that their wild-type alleles encode negative regulators acting downstream of both the cell-type and nutritional controls of meiosis. These newly defined loci do not affect either general transcription or transcription of meiotic genes expressed later in meiosis and spore formation.