Effect of varying chemoreflex stress on sympathetic neural recruitment strategies during apnea.
Effect of varying chemoreflex stress on sympathetic neural recruitment strategies during apnea.
复制标题
呼吸暂停期间不同化学反射应激对交感神经募集策略的影响。
DOI：
10.1152/jn.00319.2019
复制
发表时间：
2019
影响因子：
2.5
通讯作者：
Limberg,JacquelineK
中科院分区：
文献类型：
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作者：
Ott,ElizabethP;Baker,SarahE;Holbein,WalterW;Shoemaker,JKevin;Limberg,JacquelineK
我们试图研究呼气末呼吸暂停时不同化学反射应激对交感神经募集策略的影响。我们假设，在窒息“断点”的低阈值轴突的发射频率和概率的增加将被夸大在缺氧和衰减在高氧。对10名健康男性（31±2岁，25±1 kg/m2）进行了多单位肌肉交感神经系统活动（MSNA）（腓神经显微神经造影）的测定。在常氧、低氧（吸入O2分数：0.17±0.01）和高氧（吸入O2分数：0.92±0.03）条件下，个体完成最大自主呼气末呼吸暂停。动作电位（AP）模式从滤波的原始信号与基于小波的方法进行了检查。在含氧量正常的呼吸暂停期间，由于AP峰的频率和发生率增加（243±75至519±134 AP/min，P= 0.048; 412±133至733±185 AP/100次心跳，P= 0.02），多单位MSNA增加（P≤ 0.05）。在缺氧性呼吸暂停期间，多单位MSNA较基线增加（P< 0.01），这是由于AP的频率和发生率增加（192±59至952±266 AP/min，P< 0.01; 326±89至1，212 ±327 AP/100心跳，P< 0.01）。低通气性呼吸暂停也导致特定AP簇放电的概率增加，每次爆发超过一次（P< 0.01）。高氧可减弱呼吸暂停时MSNA的任何增加，因此未观察到多单位MSNA或AP峰频率或发生率的变化（P> 0.05）。我们的结论是，在呼吸暂停的频率和发病率的增加，增强在缺氧和抑制时，个人是高氧，突出了AP放电模式的化学反射应激的重要影响。这些结果可能对娱乐活动和/或容易发生呼吸暂停的临床条件下的循环神经控制产生影响。
We sought to examine the effect of varying chemoreflex stress on sympathetic neural recruitment strategies during end-expiratory apnea. We hypothesized that increases in the firing frequency and probability of low-threshold axons at the asphyxic “break point” would be exaggerated during hypoxia and attenuated during hyperoxia. Multiunit muscle sympathetic nervous system activity (MSNA)(peroneal nerve microneurography) was measured in 10 healthy male subjects (31±2 yr, 25±1 kg/m 2). Individuals completed maximal voluntary end-expiratory apnea under normoxic, hypoxic (inspired O 2 fraction: 0.17±0.01), and hyperoxic (inspired O 2 fraction: 0.92±0.03) conditions. Action potential (AP) patterns were examined from the filtered raw signal with wavelet-based methodology. Multiunit MSNA was increased (P≤ 0.05) during normoxic apnea, because of an increase in the frequency and incidence of AP spikes (243±75 to 519±134 APs/min, P= 0.048; 412±133 to 733±185 APs/100 heartbeats, P= 0.02). Multiunit MSNA increased from baseline (P< 0.01) during hypoxic apnea, which was due to an increase in the frequency and incidence of APs (192±59 to 952±266 APs/min, P< 0.01; 326±89 to 1,212±327 APs/100 heartbeats, P< 0.01). Hypoxic apnea also resulted in an increase in the probability of a particular AP cluster firing more than once per burst (P< 0.01). Hyperoxia attenuated any increase in MSNA with apnea, such that no changes in multiunit MSNA or frequency or incidence of AP spikes were observed (P> 0.05). We conclude that increases in frequency and incidence of APs during apnea are potentiated during hypoxia and suppressed when individuals are hyperoxic, highlighting the important impact of chemoreflex stress in AP discharge patterns. The results may have implications for neural control of the circulation in recreational activities and/or clinical conditions prone to apnea.