Respiratory symptoms in children and indoor exposure to nitrogen dioxide and gas stoves
Respiratory symptoms in children and indoor exposure to nitrogen dioxide and gas stoves
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DOI：
10.1164/ajrccm.158.3.9701084
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发表时间：
1998-09-01
影响因子：
24.7
通讯作者：
Abramson, MJ
中科院分区：
文献类型：
--
作者：
Garrett, MH;Hooper, MA;Abramson, MJ
澳大利亚维多利亚州拉特罗布山谷的80户家庭使用被动采样器测量了二氧化氮水平。约148名7至14岁的儿童被招募为研究参与者，其中53人患有哮喘。通过呼吸问卷、皮肤点刺试验和峰值流量测量来研究这些儿童的健康结果。二氧化氮浓度较低，室内中位数为11.6微克/立方米(3)(6.0 ppb)，最高为246微克/立方米(3)(128 Ppb)。呼吸道症状在接触煤气炉的儿童中更常见(优势比2.3[95%可信区间1.0-5.2]，调整了父母过敏、父母哮喘和性别)。接触二氧化氮是呼吸道症状的边缘危险因素，存在剂量-反应关系(p=0.09)。即使在调整了二氧化氮水平(优势比2.2[1.0-4.8])后，接触CAS炉子仍是呼吸系统症状的重要危险因素，这表明除了与使用燃气炉相关的平均二氧化氮暴露外，还有额外的风险。与接触煤气炉或二氧化氮的非特应性儿童相比，特应性儿童出现呼吸道症状的风险往往更高，但差异并不显著。
Nitrogen dioxide levels were measured in 80 homes in the Latrobe Valley, Victoria, Australia, using passive samplers. Some 148 children between 7 and 14 yr of age were recruited as study participants, 53 of whom had asthma. Health outcomes for the children were studied using a respiratory questionnaire, skin prick tests, and peak flow measurements. Nitrogen dioxide concentrations were low, with an indoor median of 11.6 mu g/m(3) (6.0 ppb), and a maximum of 246 mu g/m(3) (128 ppb). Respiratory symptoms were more common in children exposed to a gas stove (odds ratio 2.3 [95% CI 1.0-5.2], adjusted for parental allergy, parental asthma, and sex). Nitrogen dioxide exposure was a marginal risk factor for respiratory symptoms, with a dose-response association present (p = 0.09). Cas stove exposure was a significant risk factor for respiratory symptoms even after adjusting for nitrogen dioxide levels (odds ratio 2.2 [1.0-4.8]), suggesting an additional risk apart from the average nitrogen dioxide exposure associated with gas stove use. Atopic children tended to have a greater risk of respiratory symptoms compared with nonatopic children with exposure to gas stoves or nitrogen dioxide, but the difference was not significant.