Inhibition of chemotaxis by organic acids from anaerobes may prevent a purulent response in bacterial vaginosis
Inhibition of chemotaxis by organic acids from anaerobes may prevent a purulent response in bacterial vaginosis
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DOI：
10.1099/0022-1317-49-11-1023
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发表时间：
2000-11-01
影响因子：
3
通讯作者：
Jones, BM
中科院分区：
文献类型：
--
作者：
Al-Mushrif, S;Eley, A;Jones, BM
据推测，与细菌性阴道病 (BV) 相关的厌氧菌产生的某些有机酸可以预防这种感染的化脓反应。将不同浓度的纯琥珀酸、乙酸和乳酸与单核细胞系（MonoMac 6）体外培养，琥珀酸产生高度的趋化性抑制；乙酸和乳酸分别表现出较低的抑制作用和无抑制作用。琥珀酸和乙酸：在患有 BV 的妇女的阴道液以及普雷沃菌属和动杆菌属的培养物上清液中检测到高浓度的酸；这些酸会损害 MonoMac 6 细胞的体外趋化性。正常女性的阴道液和乳酸菌培养物上清液。对趋化性没有影响。
It has been postulated that certain organic acids produced by the anaerobes associated with bacterial vaginosis (BV) could prevent a purulent response in this infection. Varying concentrations of pure succinic, acetic and lactic acids were incubated in vitro with a monocytic cell line (MonoMac 6), High inhibition of chemotaxis was produced by succinic acid; lower inhibition and no inhibition was shown by acetic acid and lactic acid respectively. Succinic and acetic: acids were detected in high concentrations in the vaginal fluid of women with BV and in culture supernates of Prevotella and Mobiluncus spp,; these acids impaired chemotaxis of MonoMac 6 cells in vitro. The vaginal fluids of normal women and the culture supernates of Lactobacillus spp. had no effect on chemotaxis.