CHLORHEXIDINE COMPARED WITH OTHER LOCALLY DELIVERED ANTIMICROBIALS - A SHORT REVIEW
CHLORHEXIDINE COMPARED WITH OTHER LOCALLY DELIVERED ANTIMICROBIALS - A SHORT REVIEW
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DOI：
10.1111/j.1600-051x.1986.tb01434.x
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发表时间：
1986-11-01
影响因子：
6.7
通讯作者：
ADDY, M
中科院分区：
文献类型：
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作者：
ADDY, M
基于细菌菌斑与慢性牙龈炎的发生和慢性牙周炎的进展的关联，化学抗菌斑剂已被用于牙周病的预防和治疗。在龈上菌斑控制方案中，氯己定尚未被取代为化学抗菌斑剂，尽管其他化合物已被证明是有用的。然而，氯己定和其他阳离子防腐剂的局部副作用限制了其长期用于预防。特别是外部牙齿染色仍然是最大的问题。氯己定的短期抗菌斑用途包括：（1）在治疗的初始口腔卫生阶段作为机械清洁的辅助，（2）在机械口腔卫生困难的情况下，包括（i）术后。(ii)颌间固定，（iii）固定正畸治疗，（iv）身体和智力残疾的人，（v）具有口腔表现的系统性疾病，如白血病。最近对氯己定的兴趣来自于在治疗慢性牙周炎中龈下递送化合物。这样的方法已经将洗必泰的使用扩展到通过常规手段（例如刷牙或漱口）局部递送的抗微生物药物的作用难以到达的区域。现有证据表明，氯己定可能不如一些抗菌药物有效，这些抗菌药物的活性对那些被认为对牙周组织特别致病的生物体更具特异性。
Based on the association of bacterial plaque with the initiation of chronic gingivitis and progression of chronic periodontitis, chemical antiplaque agents have been employed both in prevention of periodontal disease and its treatment. In supragingival plaque control regimens, chlorhexidine has not been superceded as a chemical anti‐plaque agent, although other compounds have been shown to be useful. The local side‐effects of chlorhexidine and other cationic antiseptics, however, limit their long‐term use for prevention. Extrinsic tooth staining in particular remains the greatest problem. Short‐term anti‐plaque uses for chlorhexidine include (1) as an adjunct to mechanical cleaning in the initial oral hygiene phase of treatment, (2) in situations where mechanical oral hygiene is difficult, including (i) postsurgery. (ii) intermaxillary fixation, (iii) fixed orthodontic therapy, (iv) physically and mentally handicapped individuals, (v) systemic diseases with oral manifestations such as leukaemia. More recent interest in chlorhexidine has resulted from the delivery of compounds subgingivally in the treatment of chronic periodontitis. Such methods have extended the use of chlorhexidine into areas inaccessible to the action of antimicrobial drugs delivered locally by conventional means, such as tooth brushing or mouth rinsing. Available evidence suggests that chlorhexidine may not be as effective as some antimicrobial drugs whose activity is more specific for those organisms considered particularly pathogenic to the periodontal tissues.