Control of staphylococcal adhesion to polymethylmethacrylate and enhancement of susceptibility to antibiotics by poloxamer 407
Control of staphylococcal adhesion to polymethylmethacrylate and enhancement of susceptibility to antibiotics by poloxamer 407
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DOI：
10.1128/aac.44.4.1093-1096.2000
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发表时间：
2000-04-01
影响因子：
4.9
通讯作者：
Rouveix, B
中科院分区：
文献类型：
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作者：
Veyries, ML;Faurisson, F;Rouveix, B
我们研究了泊洛沙姆 407 (P407) 的抗粘连作用，以及对残留粘连葡萄球菌抗菌敏感性的改变。无论聚甲基丙烯酸甲酯在粘附测定之前还是期间暴露于 P407，细菌粘附均被显着抑制（77% 至 99.9% 以上）。此外，残留的粘附葡萄球菌似乎对抗生素活性更敏感，这表明P407与抗生素的组合可能是预防异物感染的有前途的方法。
We studied the antiadhesive effect of Poloxamer 407 (P407), together with modifications in the antimicrobial susceptibility of residual adherent staphylococci. Bacterial adherence was markedly inhibited (77% to more than 99.9%), whether polymethylmethacrylate was exposed to P407 before or during the adherence assay. Furthermore, residual adherent staphylococci appeared to be more susceptible to antibiotic activity, suggesting that combination of P407 with antibiotics could be a promising approach to the prevention of infection of foreign material.