Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects.
Association between Dietary Vitamin C Intake and Risk of Prostate Cancer: A Meta-analysis Involving 103,658 Subjects.
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膳食维生素 C 摄入量与前列腺癌风险之间的关联：一项涉及 103,658 名受试者的荟萃分析
DOI：
10.7150/jca.12162
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发表时间：
2015
影响因子：
3.9
通讯作者：
Wu H
中科院分区：
文献类型：
--
作者：
Bai XY;Qu X;Jiang X;Xu Z;Yang Y;Su Q;Wang M;Wu H
我们试图系统地确定维生素C的饮食摄入量与前列腺癌风险之间的关系。检索PubMed和Embase，以获得2015年2月之前发表的合格研究。纳入了队列或病例对照研究，这些研究报告了维生素C摄入量与前列腺癌风险之间相关性的相对风险（RR）/比值比（OR）估计值及其95%置信区间（CI）。最终获得了18项关于膳食维生素C摄入量的研究，共有103，658名受试者。最高与最低膳食维生素C摄入量类别的前列腺癌合并RR为0.89（95%CI：0.83 - 0.94; p = 0.000），有中度异质性的证据（I2 = 39.4%，p = 0.045）。荟萃回归分析表明，研究设计占异质性的主要比例。根据研究设计对整个研究进行分层，队列研究的合并RR为0.92（95%CI：0.86 - 0.99，p = 0.027），病例对照研究的合并RR为0.80（95%CI：0.71 - 0.89，p = 0.000），两个亚组均无异质性。在剂量-反应分析中，膳食维生素C摄入量与前列腺癌风险之间建立了反向线性关系，150 mg/天膳食维生素C摄入量的RR为0.91在总体研究中为0.95（95%CI：0.90 - 0.99，p = 0.039），在队列研究中为0.79（95%CI：0.69 - 0.91，p = 0.001）。总之，在这项荟萃分析中，从食物中摄入维生素C与前列腺癌风险呈负相关。
We attempted to systematically determine the association between dietary intake of vitamin C and risk of prostate cancer. PubMed and Embase were searched to obtain eligible studies published before February 2015. Cohort or case-control studies that reported the relative risk (RR)/odds ratio (OR) estimates with 95% confidence intervals (CIs) for the association between vitamin C intake and prostate cancer risk were included. Eighteen studies regarding dietary vitamin C intake were finally obtained, with a total of 103,658 subjects. The pooled RR of prostate cancer for the highest versus the lowest categories of dietary vitamin C intake was 0.89 (95%CI: 0.83-0.94; p = 0.000) with evidence of a moderate heterogeneity (I2 = 39.4%, p = 0.045). Meta-regression analysis suggested that study design accounted for a major proportion of the heterogeneity. Stratifying the overall study according to study design yielded pooled RRs of 0.92 (95%CI: 0.86-0.99, p = 0.027) among cohort studies and 0.80 (95%CI: 0.71-0.89, p = 0.000) among case-control studies, with no heterogeneity in either subgroup. In the dose-response analysis, an inverse linear relationship between dietary vitamin C intake and prostate cancer risk was established, with a 150 mg/day dietary vitamin C intake conferred RRs of 0.91 (95%CI: 0.84-0.98, p = 0.018) in the overall studies, 0.95 (95%CI: 0.90-0.99, p = 0.039) in cohort studies, and 0.79 (95%CI: 0.69-0.91, p = 0.001) in case-control studies. In conclusion, intake of vitamin C from food was inversely associated with prostate cancer risk in this meta-analysis.