Long-term efficacy of proton pump inhibitors as a treatment modality for eosinophilic esophagitis.
Long-term efficacy of proton pump inhibitors as a treatment modality for eosinophilic esophagitis.
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DOI：
10.1016/j.dld.2022.03.006
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发表时间：
2022-09
影响因子：
4.5
通讯作者：
Dellon, Evan S.
中科院分区：
文献类型：
--
作者：
Thakkar, Kisan P.;Fowler, Mark;Keene, Staci;Iuga, Alina;Dellon, Evan S.
Proton pump inhibitors (PPIs) are a first-line treatment for EoE, but data are limited concerning response durability. We aimed to determine long-term outcomes in EoE patients responsive to PPI-therapy. We conducted a retrospective cohort study of newly diagnosed adults with EoE who had initial histologic response (<15 eosinophils per high-power-field) to PPI-only therapy. We extracted data regarding their subsequent clinical course and outcomes. We compared findings between the initial PPI- response endoscopy and the final endoscopy, and assessed factors associated with loss of PPI response. Of 138 EoE patients with initial histologic response to PPI, 50 had long-term endoscopic follow-up, 40 had clinical follow-up, 10 changed treatments, and 38 had no long-term follow-up. Of those with endoscopic follow-up, mean follow-up-time was 3.6±2.9 years; 30 and 32 patients (60%; 64%) maintained histologic and symptom responses, respectively. However, fibrotic endoscopic findings of EoE were unchanged. Younger age (aOR 1.05, 95% CI: 1.01–1.11) and dilation prior to PPI treatment (aOR 0.21, 95% CI: 0.05–0.83) were the only factors associated with long-term loss of PPI response. Long-term histologic and clinical response rates for PPI therapy were 60% and 64%, respectively. Younger age and dilation at baseline were associated with histologic loss of response. These data can inform long-term EoE treatment selection.
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影响因子：
24.5
作者：
Cheng E;Zhang X;Huo X;Yu C;Zhang Q;Wang DH;Spechler SJ;Souza RF
通讯作者：
Souza RF
DOI：
10.1016/j.cgh.2015.08.040
发表时间：
2016-01
期刊：
Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association
影响因子：
--
作者：
Dellon ES;Cotton CC;Gebhart JH;Higgins LL;Beitia R;Woosley JT;Shaheen NJ
通讯作者：
Shaheen NJ
DOI：
10.1038/ajg.2013.363
发表时间：
2013-12
期刊：
The American journal of gastroenterology
影响因子：
--
作者：
Dellon ES;Speck O;Woodward K;Gebhart JH;Madanick RD;Levinson S;Fritchie KJ;Woosley JT;Shaheen NJ
通讯作者：
Shaheen NJ
影响因子：
7.6
作者：
Laserna-Mendieta, Emilio J.;Casabona, Sergio;Lucendo, Alfredo J.
通讯作者：
Lucendo, Alfredo J.
影响因子：
12.6
作者：
Hirano, Ikuo;Collins, Margaret H.;Dellon, Evan S.
通讯作者：
Dellon, Evan S.