Chain migration of neuronal precursors
Chain migration of neuronal precursors
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DOI：
10.1126/science.271.5251.978
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发表时间：
1996-02-16
期刊：
影响因子：
56.9
通讯作者：
AlvarezBuylla, A
中科院分区：
文献类型：
--
作者：
Lois, C;GarciaVerdugo, JM;AlvarezBuylla, A
在成年小鼠的大脑中，在侧脑室的脑室下区分裂的细胞迁移到5毫米到嗅球，在那里它们分化成神经元。这些迁移的细胞被发现移动链通过一个明确的途径，吻迁移流。连续切片的电子显微镜分析表明，这些链只包含紧密并列，延长的成神经细胞膜专业化连接。第二种细胞类型，其中含有胶质细胞酸性蛋白，包裹迁移成神经细胞的链。因此，在链迁移，神经前体移动相互关联，而不是由放射状胶质或轴突纤维的指导。
In the brain of adult mice, cells that divide in the subventricular zone of the lateral ventricle migrate up to 5 millimeters to the olfactory bulb where they differentiate into neurons. These migrating cells were found to move as chains through a well-defined pathway, the rostral migratory stream. Electron microscopic analysis of serial sections showed that these chains contained only closely apposed, elongated neuroblasts connected by membrane specializations. A second cell type, which contained glial fibrillary acidic protein, ensheathed the chains of migrating neuroblasts. Thus, during chain migration, neural precursors moved associated with each other and were not guided by radial glial or axonal fibers.