Language dominance in neurologically normal and epilepsy subjects - A functional MRI study
Language dominance in neurologically normal and epilepsy subjects - A functional MRI study
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DOI：
10.1093/brain/122.11.2033
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发表时间：
1999-11-01
期刊：
影响因子：
14.5
通讯作者：
Mueller, WM
中科院分区：
文献类型：
--
作者：
Springer, JA;Binder, JR;Mueller, WM
语言优势和影响语言偏侧化的因素进行了研究，在右撇子，神经正常的科目（n = 100）和右撇子癫痫患者（n = 50）使用功能性MRI。增加血液氧合依赖的信号在语义语言激活任务相对于非语言，听觉辨别任务提供了一个指标的语言系统偏侧化，正如预期的那样，大多数的两组显示左半球的优势，虽然连续的激活不对称是明显的，几乎所有的科目显示一定程度的右半球激活。使用分类优势分类，94%的正常受试者被认为是左半球占主导地位，6%的人有双边，大致对称的语言表征。癫痫组语言优势变异较大，78%为左半球优势，16%为对称型，6%为右半球优势。癫痫组非典型语言优势与脑损伤年龄早、右手优势弱有关。正常组的语言偏侧化与年龄呈弱相关，但与性别、教育程度、任务表现或家族左撇子无显著相关。
Language dominance and factors that influence language lateralization were investigated in right-handed, neurologically normal subjects (n = 100) and right-handed epilepsy patients (n = 50) using functional MRI. Increases in blood oxygenation-dependent signal during a semantic language activation task relative to a non-linguistic, auditory discrimination task provided an index of language system lateralization, As expected, the majority of both groups showed left hemisphere dominance, although a continuum of activation asymmetry was evident, with nearly all subjects showing some degree of right hemisphere activation. Using a categorical dominance classification, 94% of the normal subjects were considered left hemisphere dominant and 6% had bilateral, roughly symmetric language representation. None of the normal subjects had rightward dominance, There was greater variability of language dominance in the epilepsy group, with 78% showing left hemisphere dominance, 16% showing a symmetric pattern and 6% showing right hemisphere dominance, Atypical language dominance in the epilepsy group was associated with an earlier age of brain injury and with weaker right hand dominance. Language lateralization in the normal group was weakly related to age, but was not significantly related to sex, education, task performance or familial left-handedness.