Self-assembling morphology-tunable single-component supramolecular antibiotics for enhanced antibacterial manipulation
Self-assembling morphology-tunable single-component supramolecular antibiotics for enhanced antibacterial manipulation
复制标题
自组装形态可调单组分超分子抗生素用于增强抗菌操作
DOI：
10.1039/c9py01440c
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发表时间：
2020
影响因子：
4.6
通讯作者：
Tian Wei
中科院分区：
文献类型：
--
作者：
Song Xin;Deng Xudong;Wang Qinghua;Tian Jinjin;He Feng-Li;Hu Hai-Yu;Tian Wei
由于多重耐药菌株的出现，细菌对抗生素的耐药性问题已成为当今世界关注的一个主要问题。提出了一种具有不同自组装形态的单组分超分子抗生素，它可以有效地调节抗菌效果，并具有可回收的抗菌活性。这种超分子抗生素由阳离子聚合物接枝主客体偶联的两亲性分子组成。在超声波和氧化还原的连续刺激下，其自组装在水溶液中呈现出从球形胶束到支化聚集体再到点状组装的可逆形态转变。在三种自组装体系中，支化聚集体对大肠杆菌和金黄色葡萄球菌表现出最强的抗菌能力，这是由于其表面接枝的阳离子聚合物链具有特殊的富集态和较高的分布密度。创新地利用荧光激活蛋白成像技术深入研究了超分子抗生素的作用机制。预计自组装、单组分超分子抗生素的设计可能是对抗日益严重的耐药细菌问题的成功策略。
The problem of bacterial resistance to antibiotics has become a major cause of concern in the modern world, due to the occurrence of multidrug-resistant bacterial strains. A single-component supramolecular antibiotic with different self-assembling morphologies that can effectively regulate antibacterial efficacy and present recyclable antimicrobial activity is proposed. This supramolecular antibiotic consists of a cationic polymer-grafted host–guest-conjugated amphiphilic molecule. With sequential ultrasonic and redox stimuli, its self-assemblies presented reversible morphology transitions from spherical micelles to branched aggregates and finally to dot-like assemblies in aqueous solution. Branched aggregates showed the strongest antibacterial ability for E. coli and S. aureus amongst the three self-assemblies, owing to the special enrichment form and high distribution density of the grafted cationic polymer chains on their surfaces. Fluorogen-activating protein imaging was innovatively employed to deeply investigate the supramolecular antibiotic mechanism. It is anticipated that the design of self-assembling, single-component supramolecular antibiotics may be a successful strategy to fight against the increasingly serious problem of drug-resistant bacteria.