DOES ANTIBODY TO MYCOBACTERIAL ANTIGENS, INCLUDING LIPOARABINOMANNAN, LIMIT DISSEMINATION IN CHILDHOOD TUBERCULOSIS
DOES ANTIBODY TO MYCOBACTERIAL ANTIGENS, INCLUDING LIPOARABINOMANNAN, LIMIT DISSEMINATION IN CHILDHOOD TUBERCULOSIS
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DOI：
10.1016/0035-9203(92)90192-f
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发表时间：
1992-11-01
影响因子：
2.2
通讯作者：
MORENO, C
中科院分区：
文献类型：
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作者：
COSTELLO, AMD;KUMAR, A;MORENO, C
对来自英国的儿童、来自印度海得拉巴和孟加拉国达卡的结核病儿童的血清免疫球蛋白(Ig)G反应进行了检测，根据疾病是播散性的还是局部性的进行了分类，并与非结核对照组进行了比较。英国儿童的抗脂阿拉伯甘露聚糖(LAM)免疫球蛋白反应在6个月到3岁之间表现出明显的低谷，与报道的播散性结核病的最高发病率一致。36例播散性结核患儿对慢生分枝杆菌(富含LAM)的几何平均免疫球蛋白反应显著低于99例局限性结核患儿(对云雾分枝杆菌P
Serum immunoglobulin (Ig) G responses to a variety of mycobacterial antigens were measured in children from the UK, in children with tuberculosis from Hyderabad, India and Dhaka, Bangladesh, classified according to whether the disease was disseminated or localized, and in non-tuberculous controls. Anti-lipoarabinomannan (LAM) IgG responses in UK children showed a marked trough between 6 months and 3 years coincident with the reported peak incidence of disseminated tuberculosis. Geometric mean IgG responses to sonicates of slow-growing mycobacteria (rich in LAM) in 36 children with disseminated tuberculosis were markedly lower than in 99 children with localized tuberculous lesions (for Mycobacterium scrofulaceum P