Tracking ongoing cognition in individuals using brief, whole-brain functional connectivity patterns
Tracking ongoing cognition in individuals using brief, whole-brain functional connectivity patterns
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DOI：
10.1073/pnas.1501242112
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发表时间：
2015-07-14
影响因子：
11.1
通讯作者：
Bandettini, Peter A.
中科院分区：
文献类型：
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作者：
Gonzalez-Castillo, Javier;Hoy, Colin W.;Bandettini, Peter A.
功能性磁共振成像中的功能连接（FC）模式表现出秒级的动态行为，具有丰富的时空结构和有限的全脑准稳定FC配置（FC状态）集在时间和对象上重复出现。基于先前的证据，将认知的各个方面与组水平的局部连接中的分钟到分钟的FC变化联系起来，我们假设全脑FC状态可能反映了秒级的认知处理的全局，协调的动态。为了验证这一假设，当受试者参与任务并在任务所指示的心理状态之间转换时，他们被连续扫描。在短至22.5秒的窗口内计算的FC状态允许以近乎完美的精度对单个受试者的认知进行鲁棒跟踪。任务表现最差的受试者的准确性明显下降。空间限制FC信息在短时间尺度上的准确性下降，强调全脑FC动态的分布性质，超越单变量的幅度变化，作为有价值的认知标志。
Functional connectivity (FC) patterns in functional MRI exhibit dynamic behavior on the scale of seconds, with rich spatiotemporal structure and limited sets of whole-brain, quasi-stable FC configurations (FC states) recurring across time and subjects. Based on previous evidence linking various aspects of cognition to group-level, minute-to-minute FC changes in localized connections, we hypothesized that whole-brain FC states may reflect the global, orchestrated dynamics of cognitive processing on the scale of seconds. To test this hypothesis, subjects were continuously scanned as they engaged in and transitioned between mental states dictated by tasks. FC states computed within windows as short as 22.5 s permitted robust tracking of cognition in single subjects with near perfect accuracy. Accuracy dropped markedly for subjects with the lowest task performance. Spatially restricting FC information decreased accuracy at short time scales, emphasizing the distributed nature of whole-brain FC dynamics, beyond univariate magnitude changes, as valuable markers of cognition.