DD-diketopiperazines:: Antibiotics active against Vibrio anguillarum isolated from marine bacteria associated with cultures of Pecten maximus
DD-diketopiperazines:: Antibiotics active against Vibrio anguillarum isolated from marine bacteria associated with cultures of Pecten maximus
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DOI：
10.1021/np030233e
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发表时间：
2003-10-01
影响因子：
5.1
通讯作者：
Riguera, R
中科院分区：
文献类型：
--
作者：
Fdhila, F;Vázquez, V;Riguera, R
菌株CF-20（CECT 5719）和C-148（CECT 5718）分离自软体动物的幼虫培养物，显示产生对鳗弧菌（Vibrio anguillarum）具有强抗生活性的物质1-5（MIC：0.03-0.07 μ g/mL），鉴定为DD-二酮哌嗪环（D）-Pro-（D）-Phe（1）、环（D）-Pro-（D）-Leu（2）、环（D）-Pro-（D）-瓦尔（3），环（D）-Pro-（D）-Ile（4）和环-反式-4-OH-（D）-Pro-（D）-Phe（5）。与其他立体异构体的比较表明，鳗弧菌的抑制与二酮哌嗪系统中至少一种D-氨基酸的存在有关。这是第一次从单一天然来源中分离出一系列DD-二酮哌嗪，并描述了它们对鳗弧菌的抑制活性。
Bacterial strains CF-20 (CECT5719) and C-148 (CECT5718), isolated from cultures of larvae of molluscs, are shown to produce substances 1-5 with strong antibiotic activity against Vibrio anguillarum (MIC: 0.03-0.07 mug/mL) and identified as the DD-diketopiperazines cyclo(D)-Pro-(D)-Phe (1), cyclo(D)-Pro-(D)-Leu (2), cyclo(D)-Pro-(D)-Val (3), cyclo(D)-Pro-(D)-Ile (4), and cyclo-trans-4-OH-(D)-Pro-(D)-Phe (5). Comparison with other stereoisomers indicates that inhibition of V. anguillarum is associated with the presence of at least one D-amino acid in the diketopiperazine system. This is the first time a series of DD-diketopiperazines has been isolated from a single natural source and their inhibitory activity against V. anguillarum described.