Interactions of glutamate and capsaicin-evoked muscle pain on jaw motor functions of men.
Interactions of glutamate and capsaicin-evoked muscle pain on jaw motor functions of men.
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谷氨酸和辣椒素引起的肌肉疼痛对男性下颌运动功能的相互作用。
DOI：
10.1016/j.clinph.2010.01.015
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发表时间：
2010
期刊：
影响因子：
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通讯作者：
Arendt-Nielsen,L
中科院分区：
文献类型：
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作者：
Wang,K;Svensson,P;Sessle,BJ;Cairns,BE;Arendt-Nielsen,L
目的本研究旨在探讨谷氨酸和辣椒素引起的肌肉疼痛对人类下颌运动功能的相互作用。方法 15 名男性志愿者参与。将谷氨酸、辣椒素或等渗盐水以配对顺序随机注射到右侧或左侧咬肌中。采用双盲设计，在 4 周内每周进行两次注射，每次注射间隔 25 分钟：等渗盐水 (A1)，然后是谷氨酸 (A2)，辣椒素 (B1)，然后是谷氨酸 (B2)，等渗盐水 (C1)，然后是辣椒素 (C2)，以及谷氨酸 (D1)，然后是辣椒素 (D2)。在注射前后以及随后以5分钟的间隔记录注射前和注射后的静息肌电图（EMG）活动、最大自愿咬合力（MVBF）和最大自愿下颌张开度（MVJO），持续50分钟。在每次 MVBF 或 MVJO 颌功能期间，以 0-10 的数字评分量表记录疼痛强度。结果 D2 注射 5 分钟后静息肌电图活动显着增加（方差分析：P=0.028）。 D2 (116.1±6.1%) 和 C2 (102.1±3.4%) 注射之间 EMG 活动的百分比变化（与基线相比）显着不同（配对 t 检验：P=0.039）。注射谷氨酸或辣椒素后MVBF和MVJO均显着下降，但A2与B2、C2与D2各时间点相对下降幅度均无显着性差异（P>0.152）。 MVBF 或 MVJO 期间，D2 后的峰值疼痛等级显着高于 C2（P<0.022），而 A2 和 B2 之间的峰值疼痛等级没有显着差异（P>0.084）。疼痛等级与 MVBF 或 MVJO 之间存在显着负相关（Pearson 相关性：P<0.001）。结论结果表明，肌肉注射谷氨酸和辣椒素会引起肌肉疼痛，这可能会扰乱一些正常的下颌运动功能。意义当前的研究结果表明，外周谷氨酸和辣椒素受体机制相互作用，影响一些下颌运动和感觉（即疼痛）功能，并提供新的见解。深入了解口面部疼痛的复杂性。针对周围神经系统和受体机制的管理方法可能会阻止下颌运动功能的这种变化。
OBJECTIVEThe aim of the study was to investigate the interaction between glutamate and capsaicin-evoked muscle pain on human jaw motor functions.METHODSFifteen male volunteers participated. Glutamate or capsaicin or isotonic saline, in a paired-sequence order, was injected randomly into the right or left masseter muscle. Two injections were given in a double-blinded design 25min apart in one session/week over four weeks: isotonic saline (A1) followed by glutamate (A2), capsaicin (B1) followed by glutamate (B2), isotonic saline (C1) followed by capsaicin (C2), and glutamate (D1) followed by capsaicin (D2). The resting electromyographic (EMG) activity of the right and left masseter muscles, maximum voluntary bite force (MVBF), and maximum voluntary jaw opening (MVJO) were recorded before and after injection and subsequently at 5-min intervals for 50min. The pain intensity was recorded on a 0–10 numerical rating scale during each MVBF or MVJO jaw function.RESULTSResting EMG activity was significantly increased after 5min of D2 (ANOVA: P=0.028) injection. The percentage change (compared with baseline) in EMG activity was significantly different between D2 (116.1±6.1%) and C2 (102.1±3.4%) injections (paired t-test: P=0.039). The MVBF and MVJO were significantly decreased after injection of glutamate or capsaicin, however, there was no significant difference in the relative decrease between A2 and B2, or between C2 and D2 at any time point (P>0.152). There was a significantly higher peak pain rating after D2 compared to C2 during MVBF or MVJO (P<0.022), whereas no significant difference in peak pain ratings was found between A2 and B2 (P>0.084). There were significant negative correlations between pain ratings and MVBF or MVJO (Pearson correlation: P<0.001).CONCLUSIONSThe results indicate that intramuscular administration of glutamate and capsaicin induces muscle pain which has the potential to perturb some normal jaw motor functions.SIGNIFICANCEThe present findings suggest that peripheral glutamate and capsaicin receptor mechanisms interact to affect some jaw motor as well as sensory (i.e. pain) functions and provide new insights into the complexity of orofacial pain. Management approaches that target the peripheral nervous system and receptor mechanisms may prevent such changes in jaw motor function.