Alteration of cortico-limbic-striatal neural system in major depressive disorder and bipolar disorder
Alteration of cortico-limbic-striatal neural system in major depressive disorder and bipolar disorder
复制标题
重度抑郁症和双相情感障碍中皮质边缘纹状体神经系统的改变
DOI：
10.1016/j.jad.2017.05.025
复制
发表时间：
2017-10-15
影响因子：
6.6
通讯作者：
Tang, Yanqing
中科院分区：
文献类型：
--
作者：
Jiang, Xiaowei;Dai, Xu;Tang, Yanqing
背景：仅根据临床症状很难区分重度抑郁障碍（MDD）和双相情感障碍（BD）。这两种疾病在神经活动上的异同尚不清楚。在本研究中，我们使用低频波动幅度（ALFF）来比较重度抑郁症和双相抑郁症患者的神经激活变化。方法：对183名青少年和青壮年（MDD 57例，BD 46例，HC 80例）进行静息状态扫描。计算每个参与者的ALFF，然后使用基于体素的分析在所有组之间进行比较。结果：在皮质-边缘-纹状体神经系统核心区域有显著的诊断效果。此外，MDD表现为左侧神经活动异常，而BD表现为双侧神经系统异常。局限性：本研究未充分考虑药物、情绪状态和神经发育对神经激活的影响。结论：ALFF改变的偏侧性存在差异。MDD的改变主要发生在左半球，而BD的改变则是双侧的。
Background: It is often difficult to differentiate major depressive disorder (MDD) and bipolar disorder (BD) merely according to clinical symptoms. Similarities and differences in neural activity between the two disorders remain unclear. In current study, we use amplitude of low-frequency fluctuations (ALFF) to compare neural activation changes between MDD and BD patients.Methods: One hundred and eighty-three adolescents and young adults (57 MDD, 46 BD and 80 healthy controls, HC) were scanned during resting state. The ALFF for each participant was calculated, and were then compared among all groups using voxel-based analysis.Results: There was a significant effect of diagnosis in the core regions of cortico-limbic-striatal neural system. Furthermore, MDD showed left-sided abnormal neural activity while BD showed a bilateral abnormally in this neural system. Limitations: This study was underpowered to consider medications, mood states and neural developmental effects on the neural activation.Conclusions: Differences in lateralization of ALFF alterations were found. Alterations predominated in the left hemisphere for MDD, whereas alterations were bilateral for BD.