Th17 cells in inflammation
Th17 cells in inflammation
复制标题
DOI：
10.1016/j.intimp.2010.10.004
复制
发表时间：
2011-03-01
影响因子：
5.6
通讯作者：
Kishimoto, Tadamitsu
中科院分区：
文献类型：
--
作者：
Kimura, Akihiro;Kishimoto, Tadamitsu
幼稚T细胞是多电位前体，可分化为各种效应亚群，如辅助性T细胞1 （Th1）和Th2细胞，其特点是具有不同的功能。产生il -17的辅助性T细胞（Th17）最近被确定为辅助性T细胞的一个新亚群，也是与各种自身免疫性疾病相关的炎症介质。虽然有多种细胞因子参与Th17细胞的发育，但IL-6和tgf - β是幼稚T细胞生成Th17细胞的关键因素。另一方面，IL-6抑制tgf - β诱导的调节性T （Treg）细胞，从而抑制适应性T细胞反应并阻止自身免疫。最近的研究表明，使Treg和Th17细胞发育之间的平衡正常化是治疗各种自身免疫性和炎症性疾病的有效途径。在这里，我们回顾了Th17亚群的发现，其特性及其与几种自身免疫性疾病的关系。爱思唯尔B.V.版权所有
Naive T cells are multipotential precursors that differentiate into various effector subsets, such as T helper type 1 (Th1) and Th2 cells, which are characterized by their distinct functions. The IL-17-producing T helper (Th17) cell has been recently identified as a new subset of the T helper cell and a mediator of inflammation associated with various autoimmune diseases. Although several cytokines participate in Th17 cell development, IL-6 and TGF-beta are key factors for the generation of Th17 cells from naive T cells. On the other hand, IL-6 inhibits TGF-beta-induced regulatory T (Treg) cells, which suppress adaptive T cell responses and prevent autoimmunity. Recent studies suggest that it is an effective approach in the treatment of various autoimmune and inflammatory diseases to normalize the balance between Treg and Th17 cell development. Here, we review the discovery of the Th17 subset, its properties and relationship with several autoimmune diseases. Crown Copyright (c) 2010 Published by Elsevier B.V. All rights reserved.