Proteomics: in pursuit of effective traumatic brain injury therapeutics.
Proteomics: in pursuit of effective traumatic brain injury therapeutics.
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DOI：
10.1586/14789450.2015.1000869
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发表时间：
2015-02
影响因子：
3.4
通讯作者：
Ottens AK
中科院分区：
文献类型：
--
作者：
Lizhnyak PN;Ottens AK
Effective traumatic brain injury (TBI) therapeutics remain stubbornly elusive. Efforts in the field have been challenged by the heterogeneity of clinical TBI, with greater complexity among underlying molecular phenotypes than initially conceived. Future research must confront the multitude of factors comprising this heterogeneity, representing a big data challenge befitting the coming informatics age. Proteomics is poised to serve a central role in prescriptive therapeutic development, as it offers an efficient endpoint within which to assess post-TBI biochemistry. We examine rationale for multifactor TBI proteomic studies and the particular importance of temporal profiling in defining biochemical sequences and guiding therapeutic development. Lastly, we offer perspective on repurposing biofluid proteomics to develop theragnostic assays with which to prescribe, monitor and assess pharmaceutics for improved translation and outcome for TBI patients.
