Perspectives in magnetic resonance: NMR in the post-FFT era
Perspectives in magnetic resonance: NMR in the post-FFT era
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DOI：
10.1016/j.jmr.2013.11.014
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发表时间：
2014-04-01
影响因子：
2.2
通讯作者：
Wagner, Gerhard
中科院分区：
文献类型：
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作者：
Hyberts, Sven G.;Arthanari, Haribabu;Wagner, Gerhard
多维核磁共振谱传统上是用快速傅里叶变换（FFT）进行处理的。高场仪器的应用、大蛋白质谱的复杂性、一些无结构蛋白质的窄信号分散，以及为利用高场仪器的分辨率而记录间接维度所需增量所花费的时间，使得这种传统方法不尽如人意。除了对间接维度进行均匀采样之外，还需要开发新的程序，并且除了直接的FFT之外，还需要其他的重构方法。在这里我们讨论非均匀采样（NUS）方法以及合适的重构方法。我们预计，这些方法将成为复杂生物大分子多维核磁共振数据采集的标准方法，并将极大地提高现代生物核磁共振的能力。（c）2013爱思唯尔公司。保留所有权利。
Multi-dimensional NMR spectra have traditionally been processed with the fast Fourier transformation (FFT). The availability of high field instruments, the complexity of spectra of large proteins, the narrow signal dispersion of some unstructured proteins, and the time needed to record the necessary increments in the indirect dimensions to exploit the resolution of the highfield instruments make this traditional approach unsatisfactory. New procedures need to be developed beyond uniform sampling of the indirect dimensions and reconstruction methods other than the straight FFT are necessary. Here we discuss approaches of non-uniform sampling (NUS) and suitable reconstruction methods. We expect that such methods will become standard for multi-dimensional NMR data acquisition with complex biological macromolecules and will dramatically enhance the power of modern biological NMR. (c) 2013 Elsevier Inc. All rights reserved.