Normal brain development and aging: Quantitative analysis at in vivo MR imaging in healthy volunteers
Normal brain development and aging: Quantitative analysis at in vivo MR imaging in healthy volunteers
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DOI：
10.1148/radiology.216.3.r00au37672
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发表时间：
2000-09-01
期刊：
影响因子：
19.7
通讯作者：
Press, GA
中科院分区：
文献类型：
--
作者：
Courchesne, E;Chisum, HJ;Press, GA
目得：为了定量的神经解剖参数在健康志愿者和规范值从postmortem studies.MATERIALS和方法：磁共振（MR）图像的116名志愿者年龄在19个月至80岁进行了分析，半自动化的程序验证通过比较与手动描记。测量颅内空间、全脑、灰质（GM）、白色物质（WM）和脑脊液（CSF）。结果：整个大脑和颅内空间的增长25%-27（平均年龄，26个月;年龄范围，19-33个月）和青春期（平均年龄14岁，年龄范围12-15岁）;此后，全脑体积减小，使得志愿者（年龄范围，71-80岁）的体积与幼儿的体积相似。从早期到晚期（6-9岁），GM增加了13%。此后，GM的增长速度较慢，并在第四个十年达到一个平台;它在最老的志愿者中下降了13%。从幼儿期到第4个十年，GM WM比率呈指数下降;此后，它逐渐下降。在颅内空间，全脑，和GM-WM比的变化在体内模式与公布的postmortem data.CONCLUSION：MR图像准确地描绘了正常模式的年龄相关的颅内空间，全脑，GM，WM，和CSF的变化。这些定量MR成像数据可用于研究和临床环境中，用于检测基本神经解剖参数的异常。
PURPOSE: To quantitate neuroanatomic parameters in healthy volunteers and to compare the values with normative values from postmortem studies.MATERIALS AND METHODS: Magnetic resonance (MR) images of 116 volunteers aged 19 months to 80 years were analyzed with semiautomated procedures validated by means of comparison with manual tracings. Volumes measured included intracranial space, whole brain, gray matter (GM), white matter (WM), and cerebrospinal fluid (CSF). Results were compared with values from previous postmortem studies.RESULTS: Whole brain and intracranial space grew by 25%-27% between early childhood (mean age, 26 months; age range, 19-33 months) and adolescence (mean age, 14 years; age range, 12-15 years); thereafter, whole-brain volume decreased such that volunteers (age range, 71-80 years) had volumes similar to those of young children. GM increased 13% from early to later (6-9 years) childhood. Thereafter, GM increased more slowly and reached a plateau in the 4th decade; it decreased by 13% in the oldest volunteers. The GM WM ratio decreased exponentially from early childhood through the 4th decade; thereafter, it gradually declined. In vivo patterns of change in the intracranial space, whole brain, and GM-WM ratio agreed with published postmortem data.CONCLUSION: MR images accurately depict normal patterns of age-related change in intracranial space, whole brain, GM, WM, and CSF. These quantitative MR imaging data can be used in research studies and clinical settings for the detection of abnormalities in fundamental neuroanatomic parameters.