P-LIM, A LIM HOMEODOMAIN FACTOR, IS EXPRESSED DURING PITUITARY ORGAN AND CELL COMMITMENT AND SYNERGIZES WITH PIT-1
P-LIM, A LIM HOMEODOMAIN FACTOR, IS EXPRESSED DURING PITUITARY ORGAN AND CELL COMMITMENT AND SYNERGIZES WITH PIT-1
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DOI：
10.1073/pnas.92.7.2720
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发表时间：
1995-03-28
影响因子：
11.1
通讯作者：
ROSENFELD, MG
中科院分区：
文献类型：
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作者：
BACH, I;RHODES, SJ;ROSENFELD, MG
垂体LIM同域因子P-Lim以Rathke's pouch形式表达，并随着特定垂体细胞表型的建立而表达，提示垂体发育过程中的功能作用。P-Lim在成熟小鼠的垂体前叶和中间叶中选择性表达，同时也在发育中的腹侧神经索和脑干中短暂表达。P-Lim结合并激活垂体早期发育标记α -糖蛋白亚基基因的启动子，并与Pit-1协同激活编码终端分化标记的基因。P-Lim的LIM结构域专门与Pit-1 POU结构域相互作用，并且是与Pit-1协同相互作用所必需的，但不是基础转录激活事件所必需的。
A pituitary LIM homeodomain factor, P-Lim, is expressed as Rathke's pouch forms and as specific pituitary cell phenotypes are established, suggesting functional roles throughout pituitary development. While selectively expressed in both anterior and intermediate pituitary in mature mice, P-Lim is also transiently expressed in the developing ventral neural cord and brainstem. P-Lim binds to and activates the promoter of the alpha-glycoprotein subunit gene a marker of early pituitary development, and synergizes with Pit-1 in transcriptional activation of genes encoding terminal differentiation markers. The LIM domain of P-Lim specifically interacts with the Pit-1 POU domain and is required for synergistic interactions with Pit-1, but not for basal transcriptional activation events.