Genetic reassortment between Sathuperi and Shamonda viruses of the genus Orthobunyavirus in nature: implications for their genetic relationship to Schmallenberg virus
Genetic reassortment between Sathuperi and Shamonda viruses of the genus Orthobunyavirus in nature: implications for their genetic relationship to Schmallenberg virus
复制标题
DOI：
10.1007/s00705-012-1341-8
复制
发表时间：
2012-08-01
影响因子：
2.7
通讯作者：
Tsuda, Tomoyuki
中科院分区：
文献类型：
--
作者：
Yanase, Tohru;Kato, Tomoko;Tsuda, Tomoyuki
最近在北方欧洲发生的由施马伦贝格病毒引起的反刍动物畸形事件促使我们分析相关正布尼亚病毒的遗传特性，并阐明它们之间的关系。SATV、SHAV和DOUV的M RNA片段与Schmallenberg病毒的M RNA片段有高度的同源性，而SHAV的S和L RNA片段与Schmallenberg病毒的S和L RNA片段有高度的同源性。系统发育分析表明，Schmallenberg病毒的M RNA片段来自SATV，S和L RNA片段来自SHAV。
The recent outbreak of malformations in ruminants in Northern Europe caused by Schmallenberg virus induced us to analyze the genetic properties of the related orthobunyaviruses and clarify their relationship. The sequencing of three genomic RNA segments of Sathuperi, Shamonda and Douglas viruses (SATV, SHAV and DOUV) revealed that the M RNA segment of SATV and DOUV had a high degree of sequence identity with that of Schmallenberg virus, but the S and L RNA segments closely matched those of SHAV. Phylogenetic analysis of the three genomic RNA segments indicated that Schmallenberg virus is a reassortant, with the M RNA segment from SATV and the S and L RNA segments from SHAV.