Are increased levels of self-reported psychosocial stress, anxiety, and depression associated with fecundity?
Are increased levels of self-reported psychosocial stress, anxiety, and depression associated with fecundity?
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DOI：
10.1016/j.fertnstert.2012.05.018
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发表时间：
2012-08-01
影响因子：
6.7
通讯作者：
Pyper, Cecilia
中科院分区：
文献类型：
--
作者：
Lynch, Courtney D.;Sundaram, Rajeshwari;Pyper, Cecilia
目的：评估自我报告的压力，焦虑，抑郁和相关的结构和fecundity.Design措施之间的关联：前瞻性队列研究的妇女试图怀孕。设置：英国。患者：339名年龄在18-40岁的妇女谁是试图怀孕。干预（s）：完成每日日记长达六个周期或直到怀孕被检测到。对于每个周期，测量压力生物标志物并完成心理社会调查问卷。主要结果测量：使用离散时间生存方法计算生育率比值比（FOR）和95%置信区间，并使用贝叶斯统计技术计算特定日期的怀孕概率。结果：在339名女性中，207名（61%）在研究期间怀孕，69名（20%）未怀孕，63名（19%）退出研究。在控制了母亲年龄、产次、入组前尝试怀孕的月数、吸烟、咖啡因使用和性交频率后，我们发现大多数心理社会指标与FORs或妊娠日特异性概率之间没有关联，除了报告社会支持水平较高与较低的妇女的FOR增加。自我报告的心理社会压力，焦虑和抑郁与生育力无关。任何不利影响的压力或心理困扰的生育能力似乎并没有被检测到通过问卷管理。（Fertil Steril（R）2012;98：453-8. (C)美国生殖医学会（American Society for Reproductive Medicine）
Objective: To assess the association between self-reported measures of stress, anxiety, depression, and related constructs and fecundity.Design: Prospective cohort study of women trying to conceive.Setting: United Kingdom.Patient(s): Three hundred thirty-nine women aged 18-40 years who were attempting to conceive.Intervention(s): Completed daily diaries for up to six cycles or until pregnancy was detected. For each cycle, stress biomarkers were measured and psychosocial questionnaires were completed.Main Outcome Measures(s): Fecundability odds ratios (FORs) and 95% confidence intervals were calculated using discrete time survival methods, and the day-specific probabilities of pregnancy were calculated using Bayesian statistical techniques.Result(s): Among the 339 women, 207 (61%) became pregnant during the study, 69 (20%) did not become pregnant, and 63 (19%) withdrew. After controlling for maternal age, parity, months trying to conceive before enrollment, smoking, caffeine use, and frequency of intercourse, we found no association between most psychosocial measures and FORs or the day-specific probabilities of pregnancy save for an increased FOR for women reporting higher versus lower levels of social support.Conclusion(s): Self-reported psychosocial stress, anxiety, and depression were not associated with fecundity. Any adverse effect of stress or psychological disturbance on fecundity does not appear to be detectable via the questionnaires administered. (Fertil Steril (R) 2012;98:453-8. (C) 2012 by American Society for Reproductive Medicine.)