Immune regulation by polysaccharides: implications for skin cancer.
Immune regulation by polysaccharides: implications for skin cancer.
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DOI：
10.1016/s1011-1344(01)00210-x
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发表时间：
2001-10
期刊：
影响因子：
--
通讯作者：
F. Strickland
中科院分区：
文献类型：
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作者：
F. Strickland
紫外线辐射导致晒伤、皮肤过早老化，是人类鳞状细胞和基底细胞皮肤癌的主要环境致癌物。除了引起DNA突变外，紫外线辐射还通过抑制对高抗原性新出现的肿瘤的免疫反应而促成致癌作用。本文综述了预防紫外线诱导的免疫抑制的策略、所用药剂的作用机制以及免疫保护对预防皮肤癌的意义。本文综述了利用植物多糖来预防紫外线辐射引发的免疫损伤，这种方法超越了防晒霜吸收紫外线辐射作为减少组织损伤的一种手段。这些药剂在保存T细胞介导的免疫模型抗原在人类和实验室动物的疗效和作用机制进行了讨论。
UV radiation causes sunburn, premature aging of the skin and is the major environmental carcinogen for squamous cell and basal cell skin cancer in humans. Besides causing mutations in DNA, UV radiation contributes to carcinogenesis by suppressing immune responses to highly antigenic, newly arising neoplasms. Strategies aimed at preventing UV-induced immune suppression, the mechanism of action of the agents used, and the significance of immune protection for prevention of skin cancer are reviewed. This review focuses on the use of plant polysaccharides to prevent immune damage triggered by UV radiation, an approach that goes beyond absorption of UV radiation by sunscreens as a means of reducing tissue damage. The efficacy and mechanism of action of these agents in preserving T cell-mediated immunity to model antigens in human beings and in laboratory animals are discussed.