Time-varying inter-hemispheric coherence during corpus callosotomy
Time-varying inter-hemispheric coherence during corpus callosotomy
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DOI：
10.1016/j.clinph.2013.05.004
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发表时间：
2013-11-01
影响因子：
4.7
通讯作者：
Nakasato, Nobukazu
中科院分区：
文献类型：
--
作者：
Okumura, Eiichi;Iwasaki, Masaki;Nakasato, Nobukazu
目的：胼胝体切开术限制双侧癫痫放电的同步性。然而，胼胝体切开术中双侧同步性的瞬时变化尚不清楚。本研究调查如何以及何时双边同步性被抑制在前面，然后后面的步骤胼胝体callosotomy.Methods：术中头皮脑电图（EEG）记录同时与手术视频6例谁接受了医学上顽固性下降攻击胼胝体全切开术。结果：5例患者胼胝体切开术后4-13 Hz脑电相干性降低。在相干性的显着下降，观察只有在后一步的胼胝体切片的三名患者，但在整个两个步骤中的两个patients.Conclusions：减少半球间的连贯性并不总是与阶段的胼胝体切片。在胼胝体切开术的最后阶段，大脑半球间的连贯性下降，切片后的效果是最大化的完成。意义：连贯性下降的各种模式表明，在参与胼胝体的起源双边同步的个体差异。时变半球间脑电相干性对监测胼胝体切开术的生理完整性是有用的。(c)2013年国际临床神经生理学联合会。由Elsevier爱尔兰有限公司出版。保留所有权利。
Objective: Corpus callosotomy limits the bilateral synchrony of epileptic discharges. However, the instantaneous changes in bilateral synchrony during corpus callosotomy are unclear. The present study investigated how and when bilateral synchrony is suppressed in the anterior and then posterior steps of corpus callosotomy.Methods: Intra-operative scalp electroencephalography (EEG) was recorded simultaneously with surgical video for six patients who underwent total corpus callosotomy for medically intractable drop attacks. The time-varying EEG inter-hemispheric coherence was quantified by wavelet transform coherence and trend analysis.Results: The 4-13 Hz coherence decreased after corpus callosotomy in five patients. Significant decrease in coherence was observed only during the posterior step of callosal sectioning in three patients, but throughout both steps in two patients.Conclusions: Decrease in inter-hemispheric coherence is not always correlated with the stages of callosal sectioning. Inter-hemispheric coherence is decreased during the final stage of corpus callosotomy and the effect is maximized after sectioning is completed.Significance: Various patterns of coherence decrease suggest individual variations in the participation of the corpus callosum in the genesis of bilateral synchrony. Time-varying inter-hemispheric EEG coherence is useful to monitor the physiological completeness of corpus callosotomy. (c) 2013 International Federation of Clinical Neurophysiology. Published by Elsevier Ireland Ltd. All rights reserved.