Self-reported Antibiotic Allergy Incidence and Prevalence: Age and Sex Effects
Self-reported Antibiotic Allergy Incidence and Prevalence: Age and Sex Effects
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DOI：
10.1016/j.amjmed.2009.01.034
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发表时间：
2009-08-01
影响因子：
5.9
通讯作者：
Poon K-Y, T.
中科院分区：
文献类型：
--
作者：
Macy, Eric;Poon K-Y, T.
背景：关于门诊人群中抗生素不良反应的流行率和发生率的数据很少。当病历中注明时，这些事件通常被称为“过敏”。 目的：确定病历中记录的 2007 年美国医疗保健大型门诊人群中最常用抗生素类别的过敏流行率和发生率。方法：从圣地亚哥县 Kaiser Permanente 护理的 411,543 名患者的电子健康记录中提取药物过敏和抗生素使用数据，这些患者在 2007 年期间至少接受过一次门诊就诊。 2007 年。获得了 1995 年至 2007 年间每年的门诊抗生素使用数据。评估的抗生素类别包括青霉素类、磺胺类、头孢菌素类、四环素类、大环内酯类和喹诺酮类。结果：抗生素占药物过敏条目的大部分。使用历史较高的抗生素类别具有较高的过敏患病率。女性患者比男性患者使用更多的抗生素，并且对各类抗生素的过敏患病率更高。随着年龄的增长，男女抗生素过敏的患病率都在稳步上升。女性对各类抗生素的过敏发生率较高。女性患者中磺胺类抗生素过敏发生率最高，为 3.4%，而所有其他类别抗生素的过敏发生率为 1%-1.5%。男性中磺胺类抗生素过敏发生率最高，为 2.2%，而青霉素为 1.1%，所有其他类别抗生素为 0.5%-0.6%。 结论：女性性别、使用情况和年龄增长是导致抗生素过敏发生率较高的主要因素。磺胺类抗生素的抗生素过敏发生率最高。 (C) 2009 Elsevier Inc. 保留所有权利。美国医学杂志 (2009) 122, 778.e1-778.e7
BACKGROUND: Data on the prevalence and incidence of adverse reactions to antibiotics in outpatient populations are rare. These events are commonly called "allergy" when noted in the medical record.OBJECTIVES: Determine the prevalence and incidence of allergy, as recorded in the medical record, to the most commonly used antibiotic classes in a large outpatient population using health care in the United States during 2007.METHODS: Data for drug allergy and antibiotic use were extracted from the electronic health records of 411,543 patients cared for by Kaiser Permanente in San Diego County who had at least one outpatient visit during 2007. Outpatient antibiotic utilization data was obtained for each year between 1995 and 2007. Penicillins, sulfas, cephalosporins, tetracyclines, macrolides, and quinolones were the classes of antibiotics evaluated.RESULTS: Antibiotics account for a majority of drug allergy entries. Antibiotic classes with higher historical use have higher allergy prevalence. Female patients use more antibiotics than males, and have higher allergy prevalence rates for all classes of antibiotics. There is a steady increase in antibiotic allergy prevalence with aging for both sexes. Females have higher allergy incidence rates for all classes of antibiotics. Antibiotic allergy incidence in female patients is highest for sulfas, 3.4%, compared with 1%-1.5% for all other classes of antibiotics. Antibiotic allergy incidence in males also is highest for sulfas, 2.2%, compared with 1.1% for penicillins and 0.5%-0.6% for all other classes of antibiotics.CONCLUSIONS: Female sex, use, and increasing age are the primary factors that account for higher antibiotic allergy prevalence. Antibiotic allergy incidence is highest with sulfa class antibiotics. (C) 2009 Elsevier Inc. All rights reserved. The American Journal of Medicine (2009) 122, 778.e1-778.e7