Fibrocytes are involved in the pathogenesis of human chronic kidney disease
Fibrocytes are involved in the pathogenesis of human chronic kidney disease
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DOI：
10.1016/j.humpath.2009.10.008
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发表时间：
2010-05-01
期刊：
影响因子：
3.3
通讯作者：
Wada, Takashi
中科院分区：
文献类型：
--
作者：
Sakai, Norihiko;Furuichi, Kengo;Wada, Takashi
人类慢性肾脏疾病的存在与肾功能丧失的风险以及心血管疾病的发展相关。纤维细胞已被证明有助于器官纤维化。在这项研究中，纤维细胞的存在进行了研究，从100例慢性肾脏疾病患者的肾活检标本化学。此外，6例薄基底膜病患者作为疾病对照进行了研究。在慢性肾脏病患者中，观察到纤维细胞浸润主要在肾小球中。慢性肾脏病患者间质纤维细胞数量高于薄基底膜病患者。在慢性肾脏疾病患者中，肾小管中浸润纤维细胞的数量与肾小管间质病变的严重程度（如间质纤维化）密切相关。此外，间质纤维细胞的数量和CD 68阳性的巨噬细胞的数量之间有显着的相关性，以及尿单核细胞趋化蛋白-I/CCL 2水平。特别是，活检时间质纤维细胞数量与肾功能呈负相关。最后，在糖皮质激素治疗诱导的恢复期，间质纤维细胞和巨噬细胞的数量以及尿CCL 2水平显著降低。这些结果表明，纤维细胞可能通过与巨噬细胞以及CCL 2的相互作用参与慢性肾脏疾病的发病机制。(C)2010年爱思唯尔公司All rights reserved.
The presence of chronic kidney disease in humans is associated with a risk of kidney function loss as well as the development of cardiovascular disease. Fibrocytes have been shown to contribute to organ fibrosis. in this study, the presence of fibrocytes was investigated immunohistochemically in kidney biopsy specimens from 100 patients with chronic kidney disease. In addition, 6 patients with thin basement membrane disease were studied as a disease control. In patients with chronic kidney disease, the infiltration of fibrocytes was observed mainly in the interstitium. The number of interstitial fibrocytes in patients with chronic kidney disease was higher than that in patients with thin basement membrane disease. The number of infiltrated fibrocytes in the interstitium correlated well with the severity of tubulointerstitial lesions, such as interstitial fibrosis, in patients with chronic kidney disease. In addition, there were significant correlations between the number of interstitial fibrocytes and the number of CD68-positive macrophages in the interstitium as well as urinary monocyte chemoattractant protein-I/CCL2 levels. In particular, there was an inverse correlation between the number of interstitial fibrocytes and kidney function at the time of biopsy. Finally, the numbers of interstitial fibrocytes and macrophages as well as urinary CCL2 levels were significantly decreased during convalescence induced by glucocorticoid therapy. These results suggest that fibrocytes may be involved in the pathogenesis of chronic kidney disease through the interaction with macrophages as well as CCL2. (C) 2010 Elsevier Inc. All rights reserved.