Neural actions of immunophilin ligands.
Neural actions of immunophilin ligands.
复制标题
亲免素配体的神经作用。
DOI：
10.1016/s0165-6147(97)01146-2
复制
发表时间：
1998
影响因子：
13.8
通讯作者：
Suzdak,PD
中科院分区：
文献类型：
--
作者：
Snyder,SH;Sabatini,DM;Lai,MM;Steiner,JP;Hamilton,GS;Suzdak,PD
亲免疫蛋白是免疫抑制药物（如环孢素A和FK506）的蛋白质受体，它在大脑中的含量远高于免疫系统。药物-亲免疫蛋白复合物与钙调磷酸酶结合，抑制其磷酸酶活性，导致免疫抑制作用。亲免疫蛋白FKBP-12 （FK506结合蛋白，12kDa）与ryanodine和肌醇（1,4,5）三磷酸（IP3）受体形成复合物，调节其细胞内Ca2+的生理释放。在这里，Solomon Snyder和他的同事描述了非免疫抑制剂和免疫抑制剂亲免疫蛋白配体是如何在培养系统和完整动物中对许多类型的受损神经元起神经营养作用的。它们刺激受损坐骨神经、皮质胆碱能、多巴胺和5-HT神经元功能再生的能力可能具有治疗相关性。
Immunophilins, protein receptors for immunosuppressant drugs such as cyclosporin A and FK506, are enriched far more in the brain than in the immune system. Drug–immunophilin complexes bind to calcineurin, inhibiting its phosphatase activity and leading to immunosuppressant effects. The immunophilin FKBP-12 (FK506 binding protein, 12kDa) forms a complex with the ryanodine and inositol (1,4,5) trisphosphate (IP3) receptors to regulate their physiological release of intracellular Ca2+. Here, Solomon Snyder and colleagues describe how non-immunosuppressant as well as immunosuppressant immunophilin ligands are neurotrophic for numerous classes of damaged neurones, both in culture systems and intact animals. Their ability to stimulate functional regrowth of damaged sciatic, cortical cholinergic, dopamine and 5-HT neurones may have therapeutic relevance.