Characterization and Demonstration of the Value of a Lethal Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease
Characterization and Demonstration of the Value of a Lethal Mouse Model of Middle East Respiratory Syndrome Coronavirus Infection and Disease
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DOI：
10.1128/jvi.02009-15
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发表时间：
2016-01-01
影响因子：
5.4
通讯作者：
Tseng, Chien-Te K.
中科院分区：
文献类型：
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作者：
Tao, Xinrong;Garron, Tania;Tseng, Chien-Te K.
研究中东呼吸综合征冠状病毒（MERS CoV）持续感染的发病机制和评估医疗对策需要特征化的动物模型。在这里，我们进一步表征了MERS-CoV感染和疾病的致死转基因小鼠模型，其全面表达人CD 26（hCD 26）/DPP 4。病毒的半数感染量（ID 50）和半数致死量（LD 50）估计为
Characterized animal models are needed for studying the pathogenesis of and evaluating medical countermeasures for persisting Middle East respiratory syndrome-coronavirus (MERS-CoV) infections. Here, we further characterized a lethal transgenic mouse model of MERS-CoV infection and disease that globally expresses human CD26 (hCD26)/DPP4. The 50% infectious dose (ID50) and lethal dose (LD50) of virus were estimated to be