Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
Tumor necrosis factor and lymphotoxin-alpha polymorphisms and severe malaria in African populations.
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DOI：
10.1086/596320
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发表时间：
2009-02-15
期刊：
影响因子：
--
通讯作者：
Kwiatkowski DP
中科院分区：
文献类型：
--
作者：
Clark TG;Diakite M;Auburn S;Campino S;Fry AE;Green A;Richardson A;Small K;Teo YY;Wilson J;Jallow M;Sisay-Joof F;Pinder M;Griffiths MJ;Peshu N;Williams TN;Marsh K;Molyneux ME;Taylor TE;Rockett KA;Kwiatkowski DP
肿瘤坏死因子基因（TNF）和α-光毒素基因（LTA）作为疟疾易感性的候选基因一直备受关注，其中多个多态性与严重疟疾（SM）表型相关。在一项涉及超过10，000人并包括3个非洲人群的大型研究中，我们发现证据支持冈比亚TNF-238多态性与SM之间的相关性。然而，在肯尼亚和马拉维的队列中，没有发现TNF/LTA多态性与SM相关。有人认为，调节TNF和LTA反应的因果多态性可能与基因有一定距离。因此，可能需要对冈比亚和相关人群中TNF/LTA基因及其侧翼区域的变异进行更详细的定位，以找到任何致病多态性。
The tumor necrosis factor gene (TNF) and lymphotoxin-α gene (LTA) have long attracted attention as candidate genes for susceptibility traits for malaria, and several of their polymorphisms have been found to be associated with severe malaria (SM) phenotypes. In a large study involving > 10,000 individuals and encompassing 3 African populations, we found evidence to support the reported associations between the TNF −238 polymorphism and SM in The Gambia. However, no TNF/LTA polymorphisms were found to be associated with SM in cohorts in Kenya and Malawi. It has been suggested that the causal polymorphisms regulating the TNF and LTA responses may be located some distance from the genes. Therefore, more-detailed mapping of variants across TNF/LTA genes and their flanking regions in the Gambian and allied populations may need to be undertaken to find any causal polymorphisms.
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影响因子：
4.5
作者：
Clarke R;Xu P;Bennett D;Lewington S;Zondervan K;Parish S;Palmer A;Clark S;Cardon L;Peto R;Lathrop M;Collins R;International Study of Infarct Survival (ISIS) Collaborators
通讯作者：
International Study of Infarct Survival (ISIS) Collaborators
影响因子：
30.8
作者：
Knight, JC;Udalova, I;Kwiatkowski, D
通讯作者：
Kwiatkowski, D
影响因子：
5.1
作者：
Gonzalez, JM;Portillo, MC;Saiz-Jimenez, C
通讯作者：
Saiz-Jimenez, C
影响因子：
2.1
作者：
Aidoo, M;Mcelroy, PD;Udhayakumar, V
通讯作者：
Udhayakumar, V
影响因子：
30.8
作者：
Knight, JC;Keating, BJ;Kwiatkowski, DP
通讯作者：
Kwiatkowski, DP