Group I-intron trans-splicing and mRNA editing in the mitochondria of placozoan animals
Group I-intron trans-splicing and mRNA editing in the mitochondria of placozoan animals
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DOI：
10.1016/j.tig.2009.07.003
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发表时间：
2009-09-01
影响因子：
11.4
通讯作者：
Lang, B. Franz
中科院分区：
文献类型：
--
作者：
Burger, Gertraud;Yan, Yifei;Lang, B. Franz
根据线粒体基因组结构和生殖发育，最简单的已知自由生活动物被认为是原始的、早期分化的后生动物。在这里，我们重新分析了扁形动物的线粒体DNA，报告包括一个高度非正统的，片段化和不完整的cox1基因。我们发现忽略的外显子和分裂组I内含子介导的不连续的盾形动物cox1的反式剪接。此外，我们发现，cox1的表达涉及U到C编辑，重建一个否则不变的，必不可少的组氨酸参与铜结合。这些非典型特征使扁形动物的线粒体基因和基因组结构成为衍生的而不是原始的。在后生动物的进化过程中，无论是在早期还是晚期，
Placozoa - the simplest known free-living animals have been considered primitive, early diverging metazoans based on mitochondrial genome structure and phylogeny. Here we reanalyze placozoan mitochondrial DNAs, reported to include a highly unorthodox, fragmented and incomplete cox1 gene. We discover overlooked exons and split group I introns that mediate trans-splicing of the discontinuous placozoan cox1. Furthermore, we find that cox1 expression involves U-to-C editing, reconstituting an otherwise invariant, essential histidine involved in copper binding. These atypical features qualify placozoan mitochondrial gene and genome organization as derived rather than primitive. Whether the Placozoa diverged early or late during metazoan evolution remains unresolved by mitochondrial phylogeny