Sex-Based Differences in Susceptibility to Respiratory and Systemic Pneumococcal Disease in Mice
Sex-Based Differences in Susceptibility to Respiratory and Systemic Pneumococcal Disease in Mice
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DOI：
10.1093/infdis/jir657
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发表时间：
2011-12-15
影响因子：
6.4
通讯作者：
Oggioni, Marco R.
中科院分区：
文献类型：
--
作者：
Kadioglu, Aras;Cuppone, Anna Maria;Oggioni, Marco R.
在侵袭性肺炎和脓毒症模型中研究了雄性和雌性小鼠中肺炎链球菌的全身感染。雄性小鼠被发现更容易感染，表现出更大的体重减轻，体温显着下降，死亡率显着高于雌性小鼠。对于肺炎，存活率有显著差异。随着时间的推移，雌性小鼠清除了肺部感染，而与雌性小鼠相比，雄性小鼠在感染早期的集落形成单位数量显着增加，并在感染后的前24小时内伴有较高水平的中性粒细胞募集。重要的是，与雌性小鼠相比，雄性小鼠在脓毒症和肺炎期间的促炎细胞因子水平显著增加。这些细胞因子指示T辅助1型应答。本文提供的数据描述了生存率、中性粒细胞募集和促炎细胞因子水平的惊人差异，表明对呼吸道和全身性肺炎球菌疾病的易感性存在性别差异。
Systemic infection with Streptococcus pneumoniae was investigated in male and female mice in models of invasive pneumonia and sepsis. Male mice were found to be more susceptible to infection, exhibiting greater weight loss, marked decrease in body temperature, and a significantly higher mortality rate compared with female mice. For pneumonia, there were significant differences in survival rates. Female mice cleared their lung infections over time, whereas male mice, compared with female mice, had significantly increased numbers of colony-forming units in early stages of infection accompanied by higher levels of neutrophil recruitment in the first 24 hours after infection. Importantly, there were significant increases in proinflammatory cytokine levels during both sepsis and pneumonia in male compared with female mice. These cytokines were indicative of T-helper 1-type responses. The data presented here describe surprising differences in survival rates, neutrophil recruitment, and proinflammatory cytokine levels, indicating a sex-based difference in susceptibility to respiratory and systemic pneumococcal disease.