Grandsons of alcoholics. A test of sex-linked transmission of alcohol abuse.
Grandsons of alcoholics. A test of sex-linked transmission of alcohol abuse.
复制标题
酗酒者的孙子。
作者：
L. Kaij;J. Dock
为了检验与性别相关的因素影响酒精中毒和酒精滥用发生的假设，对75名酗酒者的136名儿子与134名女儿的儿子的酒精中毒或滥用率进行了比较。在正式登记的酗酒或酗酒或两者兼而有之的频率方面，没有发现孙子组之间的实质性差异，这表明没有与性别相关的因素。总样本也被用来计算孙子的这种登记风险;孙子到50岁时的登记率为43%，大约是一般男性人口的三倍，甚至高于酗酒者兄弟的同等比率。这一结果与酒精中毒的发生与隐性基因有关的假设是不一致的，尽管它符合显性基因的假设。
To test the hypothesis of a sex-linked factor influencing the occurrence of alcoholism and alcohol abuse, alcoholism or abuse rates were compared for 136 sons of the sons vs 134 sons of the daughters of 75 alcoholics. No substantial difference between the groups of grandsons was found in frequency of officially registered alcoholism or alcohol abuse, or both, which suggests no sex-linked factor is involved. The total sample was also used to calculate the risk of such registration for the grandson; the rate of registration by the grandsons' fifth decade of life was 43%, approximately three times that of the general male population, and even higher than the equivalent rate in brothers of alcoholics. This result is incompatible with an assumption of a recessive gene being involved in the occurrence of alcoholism, though it fits with the assumption of a dominant gene.