Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.
Combined sequence-based and genetic mapping analysis of complex traits in outbred rats.
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DOI：
10.1038/ng.2644
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发表时间：
2013-07
期刊：
影响因子：
30.8
通讯作者：
Flint, Jonathan
中科院分区：
文献类型：
--
作者：
Baud, Amelie;Hermsen, Roel;Guryev, Victor;Stridh, Pernilla;Graham, Delyth;McBride, Martin W.;Foroud, Tatiana;Calderari, Sophie;Diez, Margarita;Ockinger, Johan;Beyeen, Amennai D.;Gillett, Alan;Abdelmagid, Nada;Guerreiro-Cacais, Andre Ortlieb;Jagodic, Maja;Tuncel, Jonatan;Norin, Ulrika;Beattie, Elisabeth;Ngan Huynh;Miller, William H.;Koller, Daniel L.;Alam, Imranul;Falak, Samreen;Osborne-Pellegrin, Mary;Martinez-Membrives, Esther;Canete, Toni;Blazquez, Gloria;Vicens-Costa, Elia;Mont-Cardona, Carme;Diaz-Moran, Sira;Tobena, Adolf;Hummel, Oliver;Zelenika, Diana;Saar, Kathrin;Patone, Giannino;Bauerfeind, Anja;Bihoreau, Marie-Therese;Heinig, Matthias;Lee, Young-Ae;Rintisch, Carola;Schulz, Herbert;Wheeler, David A.;Worley, Kim C.;Muzny, Donna M.;Gibbs, Richard A.;Lathrop, Mark;Lansu, Nico;Toonen, Pim;Ruzius, Frans Paul;de Bruijn, Ewart;Hauser, Heidi;Adams, David J.;Keane, Thomas;Atanur, Santosh S.;Aitman, Tim J.;Flicek, Paul;Malinauskas, Tomas;Jones, E. Yvonne;Ekman, Diana;Lopez-Aumatell, Regina;Dominiczak, Anna F.;Johannesson, Martina;Holmdahl, Rikard;Olsson, Tomas;Gauguier, Dominique;Hubner, Norbert;Fernandez-Teruel, Alberto;Cuppen, Edwin;Mott, Richard;Flint, Jonathan
全序列个体的遗传图谱正在改变我们对分子变异与复杂性状变异之间关系的理解。在这里，我们报告了一个组合的序列和遗传作图分析，在远交大鼠映射355个数量性状位点的122个表型。我们确定了涉及31种表型的35个致病基因，涉及焦虑，心脏病和多发性硬化症模型中的新基因。序列和遗传变异之间的关系出乎意料地复杂：在大约40%的数量性状基因座上，单个序列变异不能解释表型效应。使用小鼠的可比序列和映射数据，我们显示近交系大鼠的变异程度和空间模式与近交系小鼠的变异程度和空间模式显著不同，并且直链淀粉基因中的遗传变异很少导致两个物种中的相同表型。
Genetic mapping on fully sequenced individuals is transforming our understanding of the relationship between molecular variation and variation in complex traits. Here we report a combined sequence and genetic mapping analysis in outbred rats that maps 355 quantitative trait loci for 122 phenotypes. We identify 35 causal genes involved in 31 phenotypes, implicating novel genes in models of anxiety, heart disease and multiple sclerosis. The relation between sequence and genetic variation is unexpectedly complex: at approximately 40% of quantitative trait loci a single sequence variant cannot account for the phenotypic effect. Using comparable sequence and mapping data from mice, we show the extent and spatial pattern of variation in inbred rats differ significantly from those of inbred mice, and that the genetic variants in orthologous genes rarely contribute to the same phenotype in both species.
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影响因子：
9.2
作者：
Israely, I;Costa, RM;Liu, X
通讯作者：
Liu, X
影响因子：
5.2
作者：
Mayosi, BM;Keavney, B;Farrall, M
通讯作者：
Farrall, M
影响因子：
7
作者：
Huang, Guo-Jen;Shifman, Sagiv;Flint, Jonathan
通讯作者：
Flint, Jonathan
影响因子：
9.8
作者：
Ferreira, Manuel A. R.;Mangino, Massimo;Martin, Nicholas G.
通讯作者：
Martin, Nicholas G.
DOI：
10.1093/database/bar009
发表时间：
2011
期刊：
Database : the journal of biological databases and curation
影响因子：
--
作者：
Magrane M;UniProt Consortium
通讯作者：
UniProt Consortium