Gastrointestinal dysfunction and disaccharide intolerance in children infected with human immunodeficiency virus.
Gastrointestinal dysfunction and disaccharide intolerance in children infected with human immunodeficiency virus.
复制标题
人类免疫缺陷病毒感染儿童的胃肠功能障碍和二糖不耐受。
DOI：
10.1016/s0022-3476(05)82147-x
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发表时间：
1991
期刊：
影响因子：
--
通讯作者：
Perman,JA
中科院分区：
文献类型：
--
作者：
Yolken,RH;Hart,W;Oung,I;Shiff,C;Greenson,J;Perman,JA
由于胃肠道功能障碍是人类免疫缺陷病毒（HIV）感染儿童的主要问题，我们利用呼吸氢测量来确定双糖吸收不良和HIV感染儿童胃肠道功能障碍之间的关系。我们发现在这一人群中乳糖不耐症和持续性腹泻病之间有很强的相关性（p<0.007，Mann-Whitney U检验）。我们还发现了蔗糖吸收不良和持续性牙周炎的证据在三个孩子。广泛的微生物学评价未能揭示与胃肠道症状发生相关的病原体。我们的研究结果表明，双糖不耐受是一种常见的发生在艾滋病毒感染的儿童持续性腹泻疾病。可能需要仔细注意饮食摄入，以改善临床症状并保持足够的营养。
Because gastrointestinal dysfunction is a major problem in children with human immunodeficiency virus (HIV) infection, we utilized breath hydrogen measurements to determine the relationship between disaccharide malabsorption and gastrointestinal dysfunction in HIV-infected children. We found a strong association between lactose intolerance and persistent diarrheal disease in this population (p<0.007, Mann-Whitney U test). We also found evidence of sucrose malabsorption and persistent diarrheal disease in three of the children. Extensive microbiologic evaluations failed to reveal an etiologic agent related to the occurrence of gastrointestinal symptoms. Our findings indicate that disaccharide intolerance is a common occurrence in HIV-infected children with persistent diarrheal disease. Careful attention to dietary intake may be required to ameliorate clinical symptoms and to maintain adequate nutrition.