Chinese Herbal Bath Therapy for the Treatment of Knee Osteoarthritis: Meta-Analysis of Randomized Controlled Trials.
Chinese Herbal Bath Therapy for the Treatment of Knee Osteoarthritis: Meta-Analysis of Randomized Controlled Trials.
复制标题
中药浴疗法治疗膝骨关节炎：随机对照试验的荟萃分析
DOI：
10.1155/2015/949172
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Wang C
中科院分区：
文献类型：
--
作者：
Chen B;Zhan H;Chung M;Lin X;Zhang M;Pang J;Wang C
目标。传统上，中药浴疗法(CHBT)被认为具有止痛和抗炎作用。我们进行了第一次荟萃分析，评估其对膝骨性关节炎(OA)患者的益处。方法：研究方法。截至2014年10月，我们搜索了三个英文数据库和四个中文数据库。选择评估至少2周CHBT治疗膝骨性关节炎的随机试验。CHBT对临床症状的影响包括疼痛程度(通过视觉模拟评分)和总有效率，总有效率评估疼痛、身体表现和健康状况。我们使用均值差进行随机效应荟萃分析。结果。总计1618名受试者的15项研究符合资格标准。洗澡处方平均包括13种中草药，每天蒸洗膝盖20-40分钟一到两次。平均疗程3周。Meta分析结果显示，与标准西药治疗相比，疼痛改善(平均差值=−0.59分；95%可信区间[CI]，−0.83至−0.36；p<；0.00001)和总有效率(风险比=1.21；95%CI，1.15至1.28；p<；0.00001)更高。没有严重不良反应的报道。结论。中药浴疗法可能是治疗膝骨性关节炎的一种安全、有效、简便的替代疗法。进一步严格设计的随机试验是有必要的。
Objective. Chinese herbal bath therapy (CHBT) has traditionally been considered to have analgesic and anti-inflammatory effects. We conducted the first meta-analysis evaluating its benefits for patients with knee osteoarthritis (OA). Methods. We searched three English and four Chinese databases through October, 2014. Randomized trials evaluating at least 2 weeks of CHBT for knee OA were selected. The effects of CHBT on clinical symptoms included both pain level (via the visual analog scale) and total effectiveness rate, which assessed pain, physical performance, and wellness. We performed random-effects meta-analyses using mean difference. Results. Fifteen studies totaling 1618 subjects met eligibility criteria. Bath prescription included, on average, 13 Chinese herbs with directions to steam and wash around the knee for 20–40 minutes once or twice daily. Mean treatment duration was 3 weeks. Results from meta-analysis showed superior pain improvement (mean difference = −0.59 points; 95% confidence intervals [CI], −0.83 to −0.36; p < 0.00001) and higher total effectiveness rate (risk ratio = 1.21; 95% CI, 1.15 to 1.28; p < 0.00001) when compared with standard western treatment. No serious adverse events were reported. Conclusion. Chinese herbal bath therapy may be a safe, effective, and simple alternative treatment modality for knee OA. Further rigorously designed, randomized trials are warranted.