BIOSYNTHESIS OF THE LUPINE ALKALOIDS .2. SPARTEINE AND LUPANINE
BIOSYNTHESIS OF THE LUPINE ALKALOIDS .2. SPARTEINE AND LUPANINE
复制标题
DOI：
10.1139/v88-280
复制
发表时间：
1988-07-01
影响因子：
1.1
通讯作者：
SPENSER, ID
中科院分区：
文献类型：
--
作者：
GOLEBIEWSKI, WM;SPENSER, ID
与基于早期观察的预测相反，现在发现来自DL-[6- 14 C]赖氨酸和来自[6- 14 C]-Δ 1-哌啶的标记不能以相等的效率进入羽扇豆碱的三个C5区段。其中一个C5片段的标记水平显著高于其他两个C5片段，这两个片段显示相同的标记水平。提出了一种新的生物遗传模型，这是符合这些新的发现，以及与所有其他区域和立体化学证据的模式，纳入的前体是可用的。
Contrary to predictions based on earlier observations, it is now found that label from DL-[6-14C]lysine and from [6-14C]-.DELTA.1-piperideine does not enter the three C5 segments of lupanine with equal efficiency. One of the C5 segments is labelled at a significantly higher level than the other two C5 segments, which show identical levels of labelling. A new biogenetic model is proposed, which is consistent with these new findings as well as with all other regio- and stereochemical evidence on the mode of incorporation of precursors that is available.