Novel amidrazone derivatives: Design, synthesis and activity evaluation
Novel amidrazone derivatives: Design, synthesis and activity evaluation
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新型氨基腙衍生物：设计、合成和活性评价
DOI：
10.1016/j.bmc.2018.04.042
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发表时间：
2018
影响因子：
3.5
通讯作者：
Fei Hu Chen
中科院分区：
文献类型：
--
作者：
Hua Zhou;Zhi Sen Wang;Xin Hua Liu;Fei Hu Chen
A series of new 6-styryl-naphthalene-2-amidrazone derivatives were synthesized and evaluated as potential ASIC1a inhibitors. Among them, compound5eshowed the most activity to inhibit [Ca2+]i. elevation in acid-induced articular chondrocytes. Together with the important role of ASIC1a in the pathogenesis of tissue acidification diseases including rheumatoid arthritis, these results might provide a meaningful hint or inspiration in developing drugs targeting at tissue acidification diseases.
