The maternal separation paradigm and adult emotionality and cognition in male and female Wistar rats
The maternal separation paradigm and adult emotionality and cognition in male and female Wistar rats
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DOI：
10.1016/s0091-3057(99)00150-1
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发表时间：
1999-12-01
影响因子：
3.6
通讯作者：
Feldon, J
中科院分区：
文献类型：
--
作者：
Lehmann, J;Pryce, CR;Feldon, J
应激低反应期单次24小时母鼠分离可改变大鼠成体行为和神经内分泌应激反应。患多发性硬化症的动物的年龄可能是成年期影响的关键因素。我们在此报告了在雄性和雌性Wistar大鼠出生后第4天（MS4）、第9天（MS9）或第18天（MS18）进行MS对成年行为的影响。使用不相关的受试者以避免混杂的垃圾效应。对被试进行了无条件恐惧/焦虑范式（开放领域和高难度迷宫）和厌恶情境下学习范式（条件冻结、主动回避和水迷宫）的测试。与我们的预测一致，我们获得了(a)男性相对于女性的恐惧/焦虑增强的性别差异，(b)证据表明MS4产生主动回避学习和条件冻结的缺陷（趋势水平），而MS9产生主动回避和水迷宫学习的增强，(c)证据（趋势水平）表明MS的这些影响在男性中比女性更大。没有证据表明MS对非条件恐惧/焦虑范式有影响。我们得出的结论是，无论分离时的年龄如何，多发性硬化症都不能提供在厌恶情况下改变行为的稳健环境模型。(C) 1999 Elsevier Science Inc.；
A single 24-h maternal separation (MS) in the rat during the stress hyporesponsive period alters adult behavior and neuroendocrine stress response. The age of the animal at MS might be a crucial factor for effects in adulthood. We report here on adult behavioral effects of MS performed on postnatal day 4 (MS4), 9 (MS9), or 18 (MS18) in male and female Wistar rats. Unrelated subjects were used to avoid confounding litter effects. Subjects were tested on paradigms of unconditioned fear/anxiety, i.e., open field and elevated plus-maze, and on paradigms involving learning in an aversive situation, i.e., conditioned freezing, active avoidance, and water maze. In line with our predictions we obtained (a) sex differences that were consistent with enhanced fear/anxiety in males relative to females, (b) evidence that MS4 yielded deficits in active avoidance learning and conditioned freezing (trend level), whereas MS9 yielded enhanced active avoidance and water maze learning, (c) evidence (at trend level) that these effects of MS are greater in males than in females. There was no evidence for an effect of MS on paradigms of unconditioned fear/anxiety. We conclude that MS, irrespective of the age at separation, does not provide a robust environmental model of modified behavior in aversive situations. (C) 1999 Elsevier Science Inc.