Memory enhancement for emotional stimuli is impaired in early Alzheimer's disease
Memory enhancement for emotional stimuli is impaired in early Alzheimer's disease
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DOI：
10.1037/0894-4105.14.1.82
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发表时间：
2000-01-01
期刊：
影响因子：
2.4
通讯作者：
Goldstein, FC
中科院分区：
文献类型：
--
作者：
Hamann, SB;Monarch, ES;Goldstein, FC
情绪唤醒与神经系统完整个体的记忆增强有关，但尚不清楚阿尔茨海默病（AD）是否也能获得这种效果。目前的研究比较了早期AD患者和老年对照组的情绪记忆和情绪反应。参与者观看情绪激动（愉快和不愉快）和中性照片，同时评估认知和电生理反应。记忆测试采用自由回忆和再认。AD组的情绪反应正常，但情绪记忆效应（对情绪刺激与中性刺激的记忆增强）受损。回忆结果表明，这种影响是正常的愉快的刺激，但不愉快的刺激异常。这些结果表明，情绪记忆效应的神经基础可能在AD中被破坏。研究结果进行了讨论的杏仁核在调解情绪记忆的作用。
Emotional arousal is associated with enhanced memory in neurologically intact individuals, but it is unknown whether this effect is obtained in Alzheimer's disease (AD). The current study compared emotional memory and emotional reactions in patients with early AD and in older controls. Participants viewed emotionally arousing (both pleasant and unpleasant) and neutral photographs while cognitive and electrophysiological reactions were assessed. Memory was tested by free recall and recognition. Emotional reactions were normal in the AD group, but the emotional memory effect (enhanced memory for emotional vs. neutral stimuli) was impaired. Recall results indicated that this effect was normal for pleasant stimuli but abnormal for unpleasant stimuli. These results suggest that the neural basis for the emotional memory effect may be disrupted in AD. Findings are discussed in terms of the role of the amygdala in mediating emotional memory.