Low income and albuminuria among REGARDS (Reasons for Geographic and Racial Differences in Stroke) study participants.
Low income and albuminuria among REGARDS (Reasons for Geographic and Racial Differences in Stroke) study participants.
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DOI:
10.1053/j.ajkd.2012.05.010
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发表时间:
2012-11
期刊:
影响因子:
--
通讯作者:
Powe NR
中科院分区:
文献类型:
--
作者:
Crews DC;McClellan WM;Shoham DA;Gao L;Warnock DG;Judd S;Muntner P;Miller ER;Powe NR
Albuminuria is an important risk factor for progressive CKD and is more prevalent among black than among white adults. We sought to determine the association between low income and albuminuria, and if this association differs for blacks and whites. Cross-sectional study. 9,144 black and 13,684 white U.S. adults aged 45 years and older in the population-based REasons for Geographic and Racial Differences in Stroke (REGARDS) study. Self-reported annual household income category (≥$75,000, 35,000 – $74,999, $20,000 – $34,999, and <$20,000); black and white race. Albuminuria defined as high (30 to 300 mg/g) or very high (>300 mg/g) urinary albumin-creatinine ratio (ACR). Multinomial logistic regression used to examine the race-stratified association between categories of income and albuminuria (normal, high, or very high ACR). Overall, geometric mean ACR was 10.2 mg/g, and was higher for blacks (11.8 mg/g) than for whites (9.3 mg/g), p <0.001. Lower income was associated with a higher prevalence of albuminuria for both whites and blacks in unadjusted analyses. After adjustment for demographics, lifestyle factors, comorbid illnesses and estimated glomerular filtration rate, there was a trend towards a stronger association between lower income levels and high ACR among blacks [ORs of 1.38 (95% CI, 1.07 – 1.77), 1.36 (95% CI, 1.05 – 1.75), and 1.58 (95% CI, 1.21–2.05), for income levels of $35,000 – $74,999, $20,000 – $34,999, and <$20,000, respectively; reference group is those with income ≥$75,000] compared to whites [ORs of 0.95 (95% CI, 0.81 – 1.12), 0.95 (95% CI, 0.79 – 1.14), and 1.26 (95% CI, 1.02 – 1.55), respectively]; P interaction 0.08 between race and income. Results were similar for very high ACR, and subgroups of participants with diabetes or hypertension. Cross-sectional design; not all REGARDS participants provided their annual income. Lower income may be more strongly associated with albuminuria among blacks than among whites, and may be a determinant of racial disparities in albuminuria.
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DOI:
10.1126/science.1193032
发表时间:
2010-08-13
期刊:
Science (New York, N.Y.)
影响因子:
--
作者:
Genovese G;Friedman DJ;Ross MD;Lecordier L;Uzureau P;Freedman BI;Bowden DW;Langefeld CD;Oleksyk TK;Uscinski Knob AL;Bernhardy AJ;Hicks PJ;Nelson GW;Vanhollebeke B;Winkler CA;Kopp JB;Pays E;Pollak MR
通讯作者:
Pollak MR
影响因子:
12.7
作者:
Krieger, N;Sidney, S
通讯作者:
Sidney, S
影响因子:
13.6
作者:
Brotman, Daniel J.;Bash, Lori D.;Coresh, Josef
通讯作者:
Coresh, Josef
影响因子:
168.9
作者:
Matsushita, Kunihiro;van der Velde, Marije;Astor, Brad C.;Woodward, Mark;Levey, Andrew S.;de Jong, Paul E.;Coresh, Josef;Gansevoort, Ron T.
通讯作者:
Gansevoort, Ron T.
影响因子:
13.6
作者:
Halbesma, Nynke;Kuiken, Dirk-Sjoerd;Gansevoort, Ronald T.
通讯作者:
Gansevoort, Ronald T.