Drosophila Atg7
Drosophila Atg7
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DOI：
10.4161/auto.5572
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发表时间：
2008-04-01
期刊：
影响因子：
13.3
通讯作者：
Neufeld, Thomas P.
中科院分区：
文献类型：
--
作者：
Juhasz, Gabor;Neufeld, Thomas P.
自噬是溶酶体降解和回收自身物质的过程，与许多发育和病理条件有关，包括衰老、癌症、神经退化和昆虫变态。令人惊讶的是，ATG7突变果蝇能够在仅有轻微延迟的情况下完成变态，尽管自噬水平大大降低。同样，幼虫中肠的发育消除是在正常形态下进行的，这表明动物可以补偿发育过程中减少的自噬。ATG7突变成人对饥饿和氧化应激过敏，寿命较短，并在大脑中积累泛素阳性聚集体，导致神经元功能进行性下降和细胞死亡。这些结果表明，在果蝇中，正常水平的自噬在某些终末分化细胞的动态平衡和应激生存中可能发挥着比发育期间更重要的作用。
Autophagy, the lysosomal degradation and recycling of self material, has been implicated in a number of developmental and pathological conditions including aging, cancer, neurodegeneration, and insect metamorphosis. Surprisingly, Atg7 mutant flies are able to complete metamorphosis with only a slight delay, despite strongly reduced autophagy levels. Similarly, developmental elimination of the larval midgut proceeds with normal morphology, suggesting that animals can compensate for reduced autophagy during development. Atg7 mutant adults are hypersensitive to starvation and oxidative stress, live shorter, and accumulate ubiquitin-positive aggregates in the brain that lead to a progressive decline of neuronal function and cell death. These results suggest that in Drosophila, normal levels of autophagy may play a more important role in the homeostasis of certain terminally differentiated cells and stress survival than during development.